Lipoprotein associated phospholipase A2 activity & its correlation with oxidized LDL & glycaemic status in early stages of type-2 diabetes mellitus
Lipoprotein associated phospholipase A 2 (Lp-PLA 2 ) is an important risk predictor of coronary artery disease (CAD). This study was aimed to evaluate Lp-PLA 2 activity and oxidized low density lipoprotein (oxLDL) in newly diagnosed patients of type 2 diabetes mellitus and to determine the correlati...
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| Veröffentlicht in: | Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2015-01, Vol.141 (1), p.107-114 |
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| creator | Garg, Seema Madhu, S V Suneja, Shilpa |
| description | Lipoprotein associated phospholipase A 2 (Lp-PLA 2 ) is an important risk predictor of coronary artery disease (CAD). This study was aimed to evaluate Lp-PLA 2 activity and oxidized low density lipoprotein (oxLDL) in newly diagnosed patients of type 2 diabetes mellitus and to determine the correlation of Lp-PLA 2 activity with oxLDL and plasma glucose levels.
Blood samples were collected in patients with newly diagnosed type 2 diabetes (n=40) before any treatment was started and healthy controls (n=40). These were processed for estimating plasma glucose: fasting and post prandial, ox LDL, and Lp-PLA2 activity. The parameters in the two groups were compared. Correlation between different parameters was calculated by Pearson correlation analysis in both groups.
Lp-PLA 2 activity (24.48 ± 4.91 vs 18.63 ± 5.29 nmol/min/ml, P |
| doi_str_mv | 10.4103/0971-5916.154512 |
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Blood samples were collected in patients with newly diagnosed type 2 diabetes (n=40) before any treatment was started and healthy controls (n=40). These were processed for estimating plasma glucose: fasting and post prandial, ox LDL, and Lp-PLA2 activity. The parameters in the two groups were compared. Correlation between different parameters was calculated by Pearson correlation analysis in both groups.
Lp-PLA 2 activity (24.48 ± 4.91 vs 18.63 ± 5.29 nmol/min/ml, P<0.001) and oxLDL levels (52.46 ± 40.19 vs 33.26 ± 12.54 μmol/l, P<0.01) were significantly higher in patients as compared to those in controls. Lp-PLA 2 activity correlated positively with oxLDL in both controls (r=0.414, P<0.01), as well in patients (r=0.542, P<0.01). A positive correlation between Lp-PLA 2 activity and fasting plasma glucose levels was observed only in patients (r=0.348, P<0.05).
Result of this study implies that higher risk of CAD in patients with diabetes may be due to increase in Lp-PLA 2 activity during the early course of the disease. A positive correlation between enzyme activity and fasting plasma glucose indicates an association between hyperglycaemia and increased activity of Lp-PLA2. This may explain a higher occurrence of CAD in patients with diabetes. A positive correlation between oxLDL and Lp-PLA2 activity suggests that Lp-PLA2 activity may be affected by oxLDL also.</description><identifier>ISSN: 0971-5916</identifier><identifier>EISSN: 0975-9174</identifier><identifier>DOI: 10.4103/0971-5916.154512</identifier><identifier>PMID: 25857502</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism ; Adult ; Blood Glucose - metabolism ; Case-Control Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - metabolism ; Female ; Health aspects ; Humans ; Lipoproteins, LDL - metabolism ; Low density lipoproteins ; Male ; Middle Aged ; Original ; Phospholipases ; Physiological aspects ; Type 2 diabetes</subject><ispartof>Indian journal of medical research (New Delhi, India : 1994), 2015-01, Vol.141 (1), p.107-114</ispartof><rights>COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright: © Indian Journal of Medical Research 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-9cb6e4a4bee730e6de6be0083e17f7ea726ac5050ac29acf8f1aaedf82abf57e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405925/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405925/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25857502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garg, Seema</creatorcontrib><creatorcontrib>Madhu, S V</creatorcontrib><creatorcontrib>Suneja, Shilpa</creatorcontrib><title>Lipoprotein associated phospholipase A2 activity & its correlation with oxidized LDL & glycaemic status in early stages of type-2 diabetes mellitus</title><title>Indian journal of medical research (New Delhi, India : 1994)</title><addtitle>Indian J Med Res</addtitle><description>Lipoprotein associated phospholipase A 2 (Lp-PLA 2 ) is an important risk predictor of coronary artery disease (CAD). This study was aimed to evaluate Lp-PLA 2 activity and oxidized low density lipoprotein (oxLDL) in newly diagnosed patients of type 2 diabetes mellitus and to determine the correlation of Lp-PLA 2 activity with oxLDL and plasma glucose levels.
Blood samples were collected in patients with newly diagnosed type 2 diabetes (n=40) before any treatment was started and healthy controls (n=40). These were processed for estimating plasma glucose: fasting and post prandial, ox LDL, and Lp-PLA2 activity. The parameters in the two groups were compared. Correlation between different parameters was calculated by Pearson correlation analysis in both groups.
Lp-PLA 2 activity (24.48 ± 4.91 vs 18.63 ± 5.29 nmol/min/ml, P<0.001) and oxLDL levels (52.46 ± 40.19 vs 33.26 ± 12.54 μmol/l, P<0.01) were significantly higher in patients as compared to those in controls. Lp-PLA 2 activity correlated positively with oxLDL in both controls (r=0.414, P<0.01), as well in patients (r=0.542, P<0.01). A positive correlation between Lp-PLA 2 activity and fasting plasma glucose levels was observed only in patients (r=0.348, P<0.05).
Result of this study implies that higher risk of CAD in patients with diabetes may be due to increase in Lp-PLA 2 activity during the early course of the disease. A positive correlation between enzyme activity and fasting plasma glucose indicates an association between hyperglycaemia and increased activity of Lp-PLA2. This may explain a higher occurrence of CAD in patients with diabetes. A positive correlation between oxLDL and Lp-PLA2 activity suggests that Lp-PLA2 activity may be affected by oxLDL also.</description><subject>1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism</subject><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Phospholipases</subject><subject>Physiological aspects</subject><subject>Type 2 diabetes</subject><issn>0971-5916</issn><issn>0975-9174</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkk-L1TAUxYsozh_du5KAIG76TNKmbTbCY3RUKLjRdbhNb96LtE1N8kbr1_ALm9pxcEBCSHLzO4ebcLLsGaO7ktHiNZU1y4Vk1Y6JUjD-IDtPJZFLVpcP_-y367PsIoSvlDLJa_k4O-OiEbWg_Dz71drZzd5FtBOBEJy2ELEn89GFNAc7Q0Cy5wR0tDc2LuQlsTEQ7bzHAaJ1E_lu45G4H7a3P5Oyfdsm5jAsGnC0moQI8RRIskfww7KeDxiIMyQuM-ac9BY6jKk04jDYxD7JHhkYAj69XS-zL9fvPl99yNtP7z9e7dtcF7KIudRdhSWUHWJdUKx6rDqktCmQ1aZGqHkFWlBBQXMJ2jSGAWBvGg6dETUWl9mbzXc-dSP2GqfoYVCztyP4RTmw6v7NZI_q4G5UWVIhuUgGr24NvPt2whDVaINOr4AJ3SkoVqUeGKWSJvTFhh5gQGUn45KjXnG1LxPAGsZYonb_odLo1690Exqb6vcEdBNo70LwaO66Z1StEVFrBtSaAbVFJEme__vqO8HfTBS_AZEHueU</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Garg, Seema</creator><creator>Madhu, S V</creator><creator>Suneja, Shilpa</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201501</creationdate><title>Lipoprotein associated phospholipase A2 activity & its correlation with oxidized LDL & glycaemic status in early stages of type-2 diabetes mellitus</title><author>Garg, Seema ; Madhu, S V ; Suneja, Shilpa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-9cb6e4a4bee730e6de6be0083e17f7ea726ac5050ac29acf8f1aaedf82abf57e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism</topic><topic>Adult</topic><topic>Blood Glucose - metabolism</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lipoproteins, LDL - metabolism</topic><topic>Low density lipoproteins</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Phospholipases</topic><topic>Physiological aspects</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garg, Seema</creatorcontrib><creatorcontrib>Madhu, S V</creatorcontrib><creatorcontrib>Suneja, Shilpa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of medical research (New Delhi, India : 1994)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garg, Seema</au><au>Madhu, S V</au><au>Suneja, Shilpa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein associated phospholipase A2 activity & its correlation with oxidized LDL & glycaemic status in early stages of type-2 diabetes mellitus</atitle><jtitle>Indian journal of medical research (New Delhi, India : 1994)</jtitle><addtitle>Indian J Med Res</addtitle><date>2015-01</date><risdate>2015</risdate><volume>141</volume><issue>1</issue><spage>107</spage><epage>114</epage><pages>107-114</pages><issn>0971-5916</issn><eissn>0975-9174</eissn><abstract>Lipoprotein associated phospholipase A 2 (Lp-PLA 2 ) is an important risk predictor of coronary artery disease (CAD). This study was aimed to evaluate Lp-PLA 2 activity and oxidized low density lipoprotein (oxLDL) in newly diagnosed patients of type 2 diabetes mellitus and to determine the correlation of Lp-PLA 2 activity with oxLDL and plasma glucose levels.
Blood samples were collected in patients with newly diagnosed type 2 diabetes (n=40) before any treatment was started and healthy controls (n=40). These were processed for estimating plasma glucose: fasting and post prandial, ox LDL, and Lp-PLA2 activity. The parameters in the two groups were compared. Correlation between different parameters was calculated by Pearson correlation analysis in both groups.
Lp-PLA 2 activity (24.48 ± 4.91 vs 18.63 ± 5.29 nmol/min/ml, P<0.001) and oxLDL levels (52.46 ± 40.19 vs 33.26 ± 12.54 μmol/l, P<0.01) were significantly higher in patients as compared to those in controls. Lp-PLA 2 activity correlated positively with oxLDL in both controls (r=0.414, P<0.01), as well in patients (r=0.542, P<0.01). A positive correlation between Lp-PLA 2 activity and fasting plasma glucose levels was observed only in patients (r=0.348, P<0.05).
Result of this study implies that higher risk of CAD in patients with diabetes may be due to increase in Lp-PLA 2 activity during the early course of the disease. A positive correlation between enzyme activity and fasting plasma glucose indicates an association between hyperglycaemia and increased activity of Lp-PLA2. This may explain a higher occurrence of CAD in patients with diabetes. A positive correlation between oxLDL and Lp-PLA2 activity suggests that Lp-PLA2 activity may be affected by oxLDL also.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>25857502</pmid><doi>10.4103/0971-5916.154512</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism Adult Blood Glucose - metabolism Case-Control Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - metabolism Female Health aspects Humans Lipoproteins, LDL - metabolism Low density lipoproteins Male Middle Aged Original Phospholipases Physiological aspects Type 2 diabetes |
| title | Lipoprotein associated phospholipase A2 activity & its correlation with oxidized LDL & glycaemic status in early stages of type-2 diabetes mellitus |
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