STEC:O111‐HUS complicated by acute encephalopathy in a young girl was successfully treated with a set of hemodiafiltration, steroid pulse, and soluble thrombomodulin under plasma exchange

Key Clinical Message We report a 14‐year‐old girl, who developed shigatoxin‐producing E. coli (STEC)‐HUS complicated by encephalopathy. She was successfully treated with hemodiafiltration, high‐dose methylprednisolone pulse therapy, and soluble recombinant thrombomodulin under plasma exchange. von Willebrand factor multimers analysis provides potential insights into how the administered therapies might facilitate successful treatment of STEC‐HUS. We report a 14‐year‐old girl, who developed shigatoxin‐producing E. coli (STEC)‐HUS complicated by encephalopathy. She was successfully treated with hemodiafiltration, high‐dose methylprednisolone pulse therapy, and soluble recombinant thrombomodulin under plasma exchange. von Willebrand factor multimers analysis provides potential insights into how the administered therapies might facilitate successful treatment of STEC‐HUS.