Physiological stress increases renal injury in eNOS-knockout mice
African Americans have a fourfold greater likelihood of developing end-stage renal disease (ESRD) compared with Caucasians. It has been proposed that the increased prevalence may be explained by non-traditional factors such as environmental stress and psychosocial factors. In this study, we used inf...
Gespeichert in:
| Veröffentlicht in: | Hypertension research 2012-03, Vol.35 (3), p.318-324 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 324 |
|---|---|
| container_issue | 3 |
| container_start_page | 318 |
| container_title | Hypertension research |
| container_volume | 35 |
| creator | Pointer, Mildred A Daumerie, Geraldine Bridges, LaKessha Yancey, Sadiqa Howard, Kelly Davis, Wendell Huang, Paul Loscalzo, Joseph |
| description | African Americans have a fourfold greater likelihood of developing end-stage renal disease (ESRD) compared with Caucasians. It has been proposed that the increased prevalence may be explained by non-traditional factors such as environmental stress and psychosocial factors. In this study, we used infrequent running to exhaustion as a physiological stressor to mimic real life experiences, such walking up stairs when an elevator is malfunctioning or running to catch a bus, to study its effect on renal injury in a hypertensive mouse model (endothelial nitric oxide synthase-deficient mice; eNOS(-/-)). This model has previously been shown to have renal injury comparable to that observed in African Americans. The effect of physiological stress on renal injury was examined in the setting of low (0.12%), control (0.45%) and high (8%) dietary salt. Following bouts of physiological stress, eNOS(-/-) mice had significantly greater interstitial inflammation compared with unstressed eNOS(-/-) mice (two-way analysis of variance (2-ANOVA), Holm-Sidak; P |
| doi_str_mv | 10.1038/hr.2011.185 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4405173</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>22170389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c433t-3fdfef2b757b8303fd72b24d0f31a7a64b106eebe5ba157b6d7ec66a28b18c153</originalsourceid><addsrcrecordid>eNpVkN1LwzAUxYMobk6ffJe-S2dukibtizCGXzCcoD6HJE3XbF07kk7Yf2_GdOjT4d57zrnwQ-ga8Bgwze9qPyYYYAx5doKGQFmeMgLsFA1xATwtOOUDdBHCEmOSZwWcowEhIGK0GKLJW70Lrmu6hTOqSULvbQiJa423KtiQeNvGtWuXW7-LktjX-Xu6ajuz6rZ9snbGXqKzSjXBXv3oCH0-PnxMn9PZ_OllOpmlhlHap7QqK1sRLTKhc4rjKIgmrMQVBSUUZxowt1bbTCuIHl4KazhXJNeQG8joCN0fejdbvbalsW3vVSM33q2V38lOOfn_0rpaLrovyRjOQNBYcHsoML4LwdvqmAUs9yRl7eWepIwko_vm77uj9xcd_QYdj3Dn</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Physiological stress increases renal injury in eNOS-knockout mice</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Pointer, Mildred A ; Daumerie, Geraldine ; Bridges, LaKessha ; Yancey, Sadiqa ; Howard, Kelly ; Davis, Wendell ; Huang, Paul ; Loscalzo, Joseph</creator><creatorcontrib>Pointer, Mildred A ; Daumerie, Geraldine ; Bridges, LaKessha ; Yancey, Sadiqa ; Howard, Kelly ; Davis, Wendell ; Huang, Paul ; Loscalzo, Joseph</creatorcontrib><description>African Americans have a fourfold greater likelihood of developing end-stage renal disease (ESRD) compared with Caucasians. It has been proposed that the increased prevalence may be explained by non-traditional factors such as environmental stress and psychosocial factors. In this study, we used infrequent running to exhaustion as a physiological stressor to mimic real life experiences, such walking up stairs when an elevator is malfunctioning or running to catch a bus, to study its effect on renal injury in a hypertensive mouse model (endothelial nitric oxide synthase-deficient mice; eNOS(-/-)). This model has previously been shown to have renal injury comparable to that observed in African Americans. The effect of physiological stress on renal injury was examined in the setting of low (0.12%), control (0.45%) and high (8%) dietary salt. Following bouts of physiological stress, eNOS(-/-) mice had significantly greater interstitial inflammation compared with unstressed eNOS(-/-) mice (two-way analysis of variance (2-ANOVA), Holm-Sidak; P<0.01). Interestingly, eNOS(-/-) mice on a high-salt diet had greater interstitial inflammation compared with similarly stressed eNOS(-/-) mice on a low- or control-salt diet (2-ANOVA, Holm-Sidak; P<0.03). These effects of stress were independent of systolic blood pressure (141±7, 143±4, and 158±8 vs. 141±4, 138±5, 150±4 mm Hg; end of study vs. baseline, respectively). There was no significant effect of stress or dietary salt on renal injury in control wild-type mice (eNOS(+)/(+)). These data demonstrate that physiological stress exacerbates the renal injury associated with hypertension and that high-salt compounds this effect of stress. These results provide support for the idea that psychosocial and environmental factors contribute to the increased prevalence of ESRD in hypertensive African Americans.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/hr.2011.185</identifier><identifier>PMID: 22170389</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Disease Models, Animal ; Hypertension - chemically induced ; Hypertension - complications ; Kidney - drug effects ; Kidney - pathology ; Kidney - physiopathology ; Kidney Diseases - enzymology ; Kidney Diseases - physiopathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide Synthase Type III - deficiency ; Nitric Oxide Synthase Type III - genetics ; Nitric Oxide Synthase Type III - physiology ; Physical Conditioning, Animal - physiology ; Sodium Chloride, Dietary - adverse effects ; Sodium Chloride, Dietary - pharmacology ; Stress, Physiological - physiology</subject><ispartof>Hypertension research, 2012-03, Vol.35 (3), p.318-324</ispartof><rights>2011 The Japanese Society of Hypertension All rights reserved 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-3fdfef2b757b8303fd72b24d0f31a7a64b106eebe5ba157b6d7ec66a28b18c153</citedby><cites>FETCH-LOGICAL-c433t-3fdfef2b757b8303fd72b24d0f31a7a64b106eebe5ba157b6d7ec66a28b18c153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22170389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pointer, Mildred A</creatorcontrib><creatorcontrib>Daumerie, Geraldine</creatorcontrib><creatorcontrib>Bridges, LaKessha</creatorcontrib><creatorcontrib>Yancey, Sadiqa</creatorcontrib><creatorcontrib>Howard, Kelly</creatorcontrib><creatorcontrib>Davis, Wendell</creatorcontrib><creatorcontrib>Huang, Paul</creatorcontrib><creatorcontrib>Loscalzo, Joseph</creatorcontrib><title>Physiological stress increases renal injury in eNOS-knockout mice</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>African Americans have a fourfold greater likelihood of developing end-stage renal disease (ESRD) compared with Caucasians. It has been proposed that the increased prevalence may be explained by non-traditional factors such as environmental stress and psychosocial factors. In this study, we used infrequent running to exhaustion as a physiological stressor to mimic real life experiences, such walking up stairs when an elevator is malfunctioning or running to catch a bus, to study its effect on renal injury in a hypertensive mouse model (endothelial nitric oxide synthase-deficient mice; eNOS(-/-)). This model has previously been shown to have renal injury comparable to that observed in African Americans. The effect of physiological stress on renal injury was examined in the setting of low (0.12%), control (0.45%) and high (8%) dietary salt. Following bouts of physiological stress, eNOS(-/-) mice had significantly greater interstitial inflammation compared with unstressed eNOS(-/-) mice (two-way analysis of variance (2-ANOVA), Holm-Sidak; P<0.01). Interestingly, eNOS(-/-) mice on a high-salt diet had greater interstitial inflammation compared with similarly stressed eNOS(-/-) mice on a low- or control-salt diet (2-ANOVA, Holm-Sidak; P<0.03). These effects of stress were independent of systolic blood pressure (141±7, 143±4, and 158±8 vs. 141±4, 138±5, 150±4 mm Hg; end of study vs. baseline, respectively). There was no significant effect of stress or dietary salt on renal injury in control wild-type mice (eNOS(+)/(+)). These data demonstrate that physiological stress exacerbates the renal injury associated with hypertension and that high-salt compounds this effect of stress. These results provide support for the idea that psychosocial and environmental factors contribute to the increased prevalence of ESRD in hypertensive African Americans.</description><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Disease Models, Animal</subject><subject>Hypertension - chemically induced</subject><subject>Hypertension - complications</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Kidney - physiopathology</subject><subject>Kidney Diseases - enzymology</subject><subject>Kidney Diseases - physiopathology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Nitric Oxide Synthase Type III - deficiency</subject><subject>Nitric Oxide Synthase Type III - genetics</subject><subject>Nitric Oxide Synthase Type III - physiology</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Sodium Chloride, Dietary - adverse effects</subject><subject>Sodium Chloride, Dietary - pharmacology</subject><subject>Stress, Physiological - physiology</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkN1LwzAUxYMobk6ffJe-S2dukibtizCGXzCcoD6HJE3XbF07kk7Yf2_GdOjT4d57zrnwQ-ga8Bgwze9qPyYYYAx5doKGQFmeMgLsFA1xATwtOOUDdBHCEmOSZwWcowEhIGK0GKLJW70Lrmu6hTOqSULvbQiJa423KtiQeNvGtWuXW7-LktjX-Xu6ajuz6rZ9snbGXqKzSjXBXv3oCH0-PnxMn9PZ_OllOpmlhlHap7QqK1sRLTKhc4rjKIgmrMQVBSUUZxowt1bbTCuIHl4KazhXJNeQG8joCN0fejdbvbalsW3vVSM33q2V38lOOfn_0rpaLrovyRjOQNBYcHsoML4LwdvqmAUs9yRl7eWepIwko_vm77uj9xcd_QYdj3Dn</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Pointer, Mildred A</creator><creator>Daumerie, Geraldine</creator><creator>Bridges, LaKessha</creator><creator>Yancey, Sadiqa</creator><creator>Howard, Kelly</creator><creator>Davis, Wendell</creator><creator>Huang, Paul</creator><creator>Loscalzo, Joseph</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>Physiological stress increases renal injury in eNOS-knockout mice</title><author>Pointer, Mildred A ; Daumerie, Geraldine ; Bridges, LaKessha ; Yancey, Sadiqa ; Howard, Kelly ; Davis, Wendell ; Huang, Paul ; Loscalzo, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-3fdfef2b757b8303fd72b24d0f31a7a64b106eebe5ba157b6d7ec66a28b18c153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Disease Models, Animal</topic><topic>Hypertension - chemically induced</topic><topic>Hypertension - complications</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Kidney - physiopathology</topic><topic>Kidney Diseases - enzymology</topic><topic>Kidney Diseases - physiopathology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Nitric Oxide Synthase Type III - deficiency</topic><topic>Nitric Oxide Synthase Type III - genetics</topic><topic>Nitric Oxide Synthase Type III - physiology</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Sodium Chloride, Dietary - adverse effects</topic><topic>Sodium Chloride, Dietary - pharmacology</topic><topic>Stress, Physiological - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pointer, Mildred A</creatorcontrib><creatorcontrib>Daumerie, Geraldine</creatorcontrib><creatorcontrib>Bridges, LaKessha</creatorcontrib><creatorcontrib>Yancey, Sadiqa</creatorcontrib><creatorcontrib>Howard, Kelly</creatorcontrib><creatorcontrib>Davis, Wendell</creatorcontrib><creatorcontrib>Huang, Paul</creatorcontrib><creatorcontrib>Loscalzo, Joseph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pointer, Mildred A</au><au>Daumerie, Geraldine</au><au>Bridges, LaKessha</au><au>Yancey, Sadiqa</au><au>Howard, Kelly</au><au>Davis, Wendell</au><au>Huang, Paul</au><au>Loscalzo, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiological stress increases renal injury in eNOS-knockout mice</atitle><jtitle>Hypertension research</jtitle><addtitle>Hypertens Res</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>35</volume><issue>3</issue><spage>318</spage><epage>324</epage><pages>318-324</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>African Americans have a fourfold greater likelihood of developing end-stage renal disease (ESRD) compared with Caucasians. It has been proposed that the increased prevalence may be explained by non-traditional factors such as environmental stress and psychosocial factors. In this study, we used infrequent running to exhaustion as a physiological stressor to mimic real life experiences, such walking up stairs when an elevator is malfunctioning or running to catch a bus, to study its effect on renal injury in a hypertensive mouse model (endothelial nitric oxide synthase-deficient mice; eNOS(-/-)). This model has previously been shown to have renal injury comparable to that observed in African Americans. The effect of physiological stress on renal injury was examined in the setting of low (0.12%), control (0.45%) and high (8%) dietary salt. Following bouts of physiological stress, eNOS(-/-) mice had significantly greater interstitial inflammation compared with unstressed eNOS(-/-) mice (two-way analysis of variance (2-ANOVA), Holm-Sidak; P<0.01). Interestingly, eNOS(-/-) mice on a high-salt diet had greater interstitial inflammation compared with similarly stressed eNOS(-/-) mice on a low- or control-salt diet (2-ANOVA, Holm-Sidak; P<0.03). These effects of stress were independent of systolic blood pressure (141±7, 143±4, and 158±8 vs. 141±4, 138±5, 150±4 mm Hg; end of study vs. baseline, respectively). There was no significant effect of stress or dietary salt on renal injury in control wild-type mice (eNOS(+)/(+)). These data demonstrate that physiological stress exacerbates the renal injury associated with hypertension and that high-salt compounds this effect of stress. These results provide support for the idea that psychosocial and environmental factors contribute to the increased prevalence of ESRD in hypertensive African Americans.</abstract><cop>England</cop><pmid>22170389</pmid><doi>10.1038/hr.2011.185</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-9636 |
| ispartof | Hypertension research, 2012-03, Vol.35 (3), p.318-324 |
| issn | 0916-9636 1348-4214 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4405173 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Blood Pressure - drug effects Blood Pressure - physiology Disease Models, Animal Hypertension - chemically induced Hypertension - complications Kidney - drug effects Kidney - pathology Kidney - physiopathology Kidney Diseases - enzymology Kidney Diseases - physiopathology Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase Type III - deficiency Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - physiology Physical Conditioning, Animal - physiology Sodium Chloride, Dietary - adverse effects Sodium Chloride, Dietary - pharmacology Stress, Physiological - physiology |
| title | Physiological stress increases renal injury in eNOS-knockout mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T01%3A53%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Physiological%20stress%20increases%20renal%20injury%20in%20eNOS-knockout%20mice&rft.jtitle=Hypertension%20research&rft.au=Pointer,%20Mildred%20A&rft.date=2012-03-01&rft.volume=35&rft.issue=3&rft.spage=318&rft.epage=324&rft.pages=318-324&rft.issn=0916-9636&rft.eissn=1348-4214&rft_id=info:doi/10.1038/hr.2011.185&rft_dat=%3Cpubmed_cross%3E22170389%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/22170389&rfr_iscdi=true |