Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates

To determine the association between genetic variants and transition to advanced age-related macular degeneration (AMD), and to develop a predictive model and online application to assist in clinical decision making. Among 2951 subjects in the Age-Related Eye Disease Study, 834 progressed from no AM...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2015-04, Vol.56 (4), p.2192-2202
Hauptverfasser:	Seddon, Johanna M, Silver, Rachel E, Kwong, Manlik, Rosner, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Clinical and Epidemiologic Research Complement C3 - genetics Disease Progression Environment Female Follow-Up Studies Genetic Predisposition to Disease Genetic Variation Genotype Humans Incidence Macula Lutea - pathology Macular Degeneration - diagnosis Macular Degeneration - epidemiology Macular Degeneration - genetics Male Middle Aged Odds Ratio Phenotype Polymorphism, Single Nucleotide Prognosis Risk Assessment - methods Risk Factors Time Factors United States - epidemiology
Online-Zugang:	Volltext
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