Homocystein as a risk factor for developing complications in chronic renal failure
Cardiovascular diseases are leading cause of death in patients with chronic renal failure. The aim of our study was to establish connection between levels of homocysteine and traditional and nontraditional risk factors for developing cardiovascular diseases in dialysis and pre dialysis patients. We...
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| Veröffentlicht in: | Materia socio-medica 2015-04, Vol.27 (2), p.95-98 |
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| creator | Jakovljevic, Biljana Gasic, Branislav Kovacevic, Pedja Rajkovaca, Zvezdana Kovacevic, Tijana |
| description | Cardiovascular diseases are leading cause of death in patients with chronic renal failure. The aim of our study was to establish connection between levels of homocysteine and traditional and nontraditional risk factors for developing cardiovascular diseases in dialysis and pre dialysis patients.
We included 33 pre dialysis (23 in stage three and 10 in stage four of chronic kidney disease) and 43 patients receiving hemodialysis longer than six months. Besides standard laboratory parameters, levels of homocysteine and blood pressure were measured in all patients. Glomerular filtration rate was measured in pre dialysis patients and dialysis quality parameters in dialysis patients.
Homocysteine levels were elevated in all patients (19±5.42mmol/l). The connection between homocysteine levels and other cardiovascular diseases risk factors was not established in pre dialysis patients. In patients treated with hemodialysis we found negative correlation between homocysteine levels and patients' age (p |
| doi_str_mv | 10.5455/msm.2015.27.95-98 |
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We included 33 pre dialysis (23 in stage three and 10 in stage four of chronic kidney disease) and 43 patients receiving hemodialysis longer than six months. Besides standard laboratory parameters, levels of homocysteine and blood pressure were measured in all patients. Glomerular filtration rate was measured in pre dialysis patients and dialysis quality parameters in dialysis patients.
Homocysteine levels were elevated in all patients (19±5.42mmol/l). The connection between homocysteine levels and other cardiovascular diseases risk factors was not established in pre dialysis patients. In patients treated with hemodialysis we found negative correlation between homocysteine levels and patients' age (p<0.05) and positive correlation between homocysteine levels and length of dialysis (p<0.01) as well as between homocysteine and anemia parameters (erythrocytes, hemoglobin), (p<0.01). Homocysteine and LDL (and total cholesterol) were in negative correlation (p<0.01).
Homocysteine, as one of nontraditional cardiovascular diseases risk factors, is elevated in all patients with chronic renal failure and it's positive correlation with some other risk factors was found.</description><identifier>ISSN: 1512-7680</identifier><identifier>EISSN: 1986-597X</identifier><identifier>DOI: 10.5455/msm.2015.27.95-98</identifier><identifier>PMID: 26005384</identifier><language>eng</language><publisher>Bosnia and Herzegovina: Academy of Medical Sciences of Bosnia and Herzegovina</publisher><subject>Amino acids ; Cardiovascular disease ; Hemodialysis ; Original Paper ; Risk factors</subject><ispartof>Materia socio-medica, 2015-04, Vol.27 (2), p.95-98</ispartof><rights>Copyright Academy of Medical Sciences of Bosnia and Herzegovina 2015</rights><rights>Copyright: © Biljana Jakovljevic, Branislav Gasic, Pedja Kovacevic, Zvezdana Rajkovaca, Tijana Kovacevic 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2728-a792fe076ac3fb57fd437a64d08f673fd88c7b24fda46db36db164b3bc55e8c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404960/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404960/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26005384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jakovljevic, Biljana</creatorcontrib><creatorcontrib>Gasic, Branislav</creatorcontrib><creatorcontrib>Kovacevic, Pedja</creatorcontrib><creatorcontrib>Rajkovaca, Zvezdana</creatorcontrib><creatorcontrib>Kovacevic, Tijana</creatorcontrib><title>Homocystein as a risk factor for developing complications in chronic renal failure</title><title>Materia socio-medica</title><addtitle>Mater Sociomed</addtitle><description>Cardiovascular diseases are leading cause of death in patients with chronic renal failure. The aim of our study was to establish connection between levels of homocysteine and traditional and nontraditional risk factors for developing cardiovascular diseases in dialysis and pre dialysis patients.
We included 33 pre dialysis (23 in stage three and 10 in stage four of chronic kidney disease) and 43 patients receiving hemodialysis longer than six months. Besides standard laboratory parameters, levels of homocysteine and blood pressure were measured in all patients. Glomerular filtration rate was measured in pre dialysis patients and dialysis quality parameters in dialysis patients.
Homocysteine levels were elevated in all patients (19±5.42mmol/l). The connection between homocysteine levels and other cardiovascular diseases risk factors was not established in pre dialysis patients. In patients treated with hemodialysis we found negative correlation between homocysteine levels and patients' age (p<0.05) and positive correlation between homocysteine levels and length of dialysis (p<0.01) as well as between homocysteine and anemia parameters (erythrocytes, hemoglobin), (p<0.01). Homocysteine and LDL (and total cholesterol) were in negative correlation (p<0.01).
Homocysteine, as one of nontraditional cardiovascular diseases risk factors, is elevated in all patients with chronic renal failure and it's positive correlation with some other risk factors was found.</description><subject>Amino acids</subject><subject>Cardiovascular disease</subject><subject>Hemodialysis</subject><subject>Original Paper</subject><subject>Risk factors</subject><issn>1512-7680</issn><issn>1986-597X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdUUtLxjAQDKL4_gFepODFSz_TJJukF0HEFwiCKHgLaZpotG0-k1bw35viA_Ww7MLOzO4wCO1VeAEM4KhP_YLgChZELGooa7mCNqta8hJq8bCaZ6hIKbjEG2grpWeMOZZcrKMNwjEGKtkmur0MfTDvabR-KHQqdBF9eimcNmOIhcvV2jfbhaUfHgsT-mXnjR59GFKRCeYphsGbItpBd5nkuynaHbTmdJfs7lffRvfnZ3enl-X1zcXV6cl1aYggstSiJs5iwbWhrgHhWkaF5qzF0nFBXSulEQ1hrtWMtw3NVXHW0MYAWGkk3UbHn7rLqelta-wwRt2pZfS9ju8qaK_-bgb_pB7Dm2IMs5rjLHD4JRDD62TTqHqfjO06PdgwJVVxSSlQ4POtg3_Q5zDFbHpGCZAggLOMqj5RJoaUonU_z1RYzYmpnJiaE1NEqBpUPSvv_3bxw_iOiH4ArISUTw</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Jakovljevic, Biljana</creator><creator>Gasic, Branislav</creator><creator>Kovacevic, Pedja</creator><creator>Rajkovaca, Zvezdana</creator><creator>Kovacevic, Tijana</creator><general>Academy of Medical Sciences of Bosnia and Herzegovina</general><general>AVICENA, d.o.o., Sarajevo</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8C1</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150401</creationdate><title>Homocystein as a risk factor for developing complications in chronic renal failure</title><author>Jakovljevic, Biljana ; Gasic, Branislav ; Kovacevic, Pedja ; Rajkovaca, Zvezdana ; Kovacevic, Tijana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2728-a792fe076ac3fb57fd437a64d08f673fd88c7b24fda46db36db164b3bc55e8c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Amino acids</topic><topic>Cardiovascular disease</topic><topic>Hemodialysis</topic><topic>Original Paper</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jakovljevic, Biljana</creatorcontrib><creatorcontrib>Gasic, Branislav</creatorcontrib><creatorcontrib>Kovacevic, Pedja</creatorcontrib><creatorcontrib>Rajkovaca, Zvezdana</creatorcontrib><creatorcontrib>Kovacevic, Tijana</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Public Health Database</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Materia socio-medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jakovljevic, Biljana</au><au>Gasic, Branislav</au><au>Kovacevic, Pedja</au><au>Rajkovaca, Zvezdana</au><au>Kovacevic, Tijana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homocystein as a risk factor for developing complications in chronic renal failure</atitle><jtitle>Materia socio-medica</jtitle><addtitle>Mater Sociomed</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>27</volume><issue>2</issue><spage>95</spage><epage>98</epage><pages>95-98</pages><issn>1512-7680</issn><eissn>1986-597X</eissn><abstract>Cardiovascular diseases are leading cause of death in patients with chronic renal failure. The aim of our study was to establish connection between levels of homocysteine and traditional and nontraditional risk factors for developing cardiovascular diseases in dialysis and pre dialysis patients.
We included 33 pre dialysis (23 in stage three and 10 in stage four of chronic kidney disease) and 43 patients receiving hemodialysis longer than six months. Besides standard laboratory parameters, levels of homocysteine and blood pressure were measured in all patients. Glomerular filtration rate was measured in pre dialysis patients and dialysis quality parameters in dialysis patients.
Homocysteine levels were elevated in all patients (19±5.42mmol/l). The connection between homocysteine levels and other cardiovascular diseases risk factors was not established in pre dialysis patients. In patients treated with hemodialysis we found negative correlation between homocysteine levels and patients' age (p<0.05) and positive correlation between homocysteine levels and length of dialysis (p<0.01) as well as between homocysteine and anemia parameters (erythrocytes, hemoglobin), (p<0.01). Homocysteine and LDL (and total cholesterol) were in negative correlation (p<0.01).
Homocysteine, as one of nontraditional cardiovascular diseases risk factors, is elevated in all patients with chronic renal failure and it's positive correlation with some other risk factors was found.</abstract><cop>Bosnia and Herzegovina</cop><pub>Academy of Medical Sciences of Bosnia and Herzegovina</pub><pmid>26005384</pmid><doi>10.5455/msm.2015.27.95-98</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acids Cardiovascular disease Hemodialysis Original Paper Risk factors |
| title | Homocystein as a risk factor for developing complications in chronic renal failure |
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