Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

The first kinase inhibitor drug approval in 2001 initiated a remarkable decade of tyrosine kinase inhibitor drugs for oncology indications, but a void exists for serine/threonine protein kinase inhibitor drugs and central nervous system indications. Stress kinases are of special interest in neurolog...

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Veröffentlicht in:	ACS chemical neuroscience 2015-04, Vol.6 (4), p.666-680
Hauptverfasser:	Roy, Saktimayee M, Grum-Tokars, Valerie L, Schavocky, James P, Saeed, Faisal, Staniszewski, Agnieszka, Teich, Andrew F, Arancio, Ottavio, Bachstetter, Adam D, Webster, Scott J, Van Eldik, Linda J, Minasov, George, Anderson, Wayne F, Pelletier, Jeffrey C, Watterson, D. Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - physiopathology Alzheimer Disease - psychology Animals Association Learning - drug effects BASIC BIOLOGICAL SCIENCES Brain - drug effects Cell Line Disease Models, Animal Disease Progression Dose-Response Relationship, Drug Drug Evaluation, Preclinical Humans Male Memory Disorders - drug therapy Memory Disorders - physiopathology Mice, Transgenic Microsomes, Liver - drug effects Microsomes, Liver - physiology Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors Mitogen-Activated Protein Kinase 14 - metabolism Molecular Structure Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacokinetics Neuroprotective Agents - pharmacology Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacokinetics Protein Kinase Inhibitors - pharmacology Pyridazines - pharmacology Rats, Sprague-Dawley Spatial Memory - drug effects Synapses - drug effects Synapses - physiology
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