CXC chemokines and antimicrobial peptides in rhinovirus-induced experimental asthma exacerbations

Summary Rationale Rhinoviruses (RVs) are the major triggers of asthma exacerbations. We have shown previously that lower respiratory tract symptoms, airflow obstruction, and neutrophilic airway inflammation were increased in experimental RV‐induced asthma exacerbations. Objectives We hypothesized th...

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Veröffentlicht in:	Clinical and experimental allergy 2014-07, Vol.44 (7), p.930-939
Hauptverfasser:	Rohde, G., Message, S. D., Haas, J. J., Kebadze, T., Parker, H., Laza-Stanca, V., Khaitov, M. R., Kon, O. M., Stanciu, L. A., Mallia, P., Edwards, M. R., Johnston, S. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult airway epithelium Antimicrobial Cationic Peptides - metabolism Asthma - diagnosis Asthma - etiology Asthma - metabolism Asthma - physiopathology Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Bronchoalveolar Lavage Fluid - virology Case-Control Studies Chemokines, CXC - metabolism Chemotaxis, Leukocyte - immunology Disease Progression Elafin - metabolism Female Humans infection control innate immunity Male neutrophil biology Neutrophils - immunology Original Picornaviridae Infections - complications Respiratory Function Tests respiratory infection Rhinovirus Rhinovirus - immunology Young Adult
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