ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction

Polymorphisms in genes encoding adiponectin (ADIPOQ) and interleukin-6 (IL6) have been associated with adiposity and obese-related phenotypes. This study investigated the relationship of ADIPOQ and IL6 gene polymorphisms with pro-inflammatory and cardiometabolic markers in obese patients. Anthropome...

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Veröffentlicht in:	Diabetology and metabolic syndrome 2015-04, Vol.7 (1), p.34-34, Article 34
Hauptverfasser:	de Oliveira, Raquel, Moraes, Tamiris Invencioni, Cerda, Alvaro, Hirata, Mario Hiroyuki, Fajardo, Cristina Moreno, Sousa, Marcela Correia, Dorea, Egidio Lima, Bernik, Márcia Martins Silveira, Hirata, Rosario Dominguez Crespo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Fibrin Fibrinogen Genes Genetic aspects Genetic polymorphisms Health aspects Hypertension Inflammation Interleukins Leptin Obesity Tumor necrosis factor Type 2 diabetes
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Zusammenfassung:	Polymorphisms in genes encoding adiponectin (ADIPOQ) and interleukin-6 (IL6) have been associated with adiposity and obese-related phenotypes. This study investigated the relationship of ADIPOQ and IL6 gene polymorphisms with pro-inflammatory and cardiometabolic markers in obese patients. Anthropometric and body composition parameters were measured in 249 Brazilian subjects (30 to 68 yr). Metabolic and inflammatory markers and adipokines were analyzed in blood samples. ADIPOQ rs2241766 (45 T > G) and IL6 rs1800795 (-174G > C) polymorphisms were analyzed by real-time PCR and PCR-RFLP, respectively. Type 2 diabetes, hypertension, dyslipidemia and increased values of waist circumference, body fat, leptin, fibrinogen, IL-1β, hsCRP and TNFα were related to obesity (p
ISSN:	1758-5996 1758-5996
DOI:	10.1186/s13098-015-0027-2