Drug delivery strategies to enhance the permeability of the blood-brain barrier for treatment of glioma
Gliomas are amongst the most insidious and destructive types of brain cancer and are associated with a poor prognosis, frequent recurrences, and extremely high lethality despite combination treatment of surgery, radiotherapy, and chemotherapy. The existence of the blood-brain barrier (BBB) restricts...
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| Veröffentlicht in: | Drug design, development and therapy development and therapy, 2015-01, Vol.9, p.2089-2100 |
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| description | Gliomas are amongst the most insidious and destructive types of brain cancer and are associated with a poor prognosis, frequent recurrences, and extremely high lethality despite combination treatment of surgery, radiotherapy, and chemotherapy. The existence of the blood-brain barrier (BBB) restricts the delivery of therapeutic molecules into the brain and offers the clinical efficacy of many pharmaceuticals that have been demonstrated to be effective for other kinds of tumors. This challenge emphasizes the need to be able to deliver drugs effectively across the BBB to reach the brain parenchyma. Enhancement of the permeability of the BBB and being able to transport drugs across it has been shown to be a promising strategy to improve drug absorption and treatment efficacy. This review highlights the innovative technologies that have been introduced to enhance the permeability of the BBB and to obtain an optimal distribution and concentration of drugs in the brain to treat gliomas, such as nanotechniques, hyperthermia techniques, receptor-mediated transport, cell-penetrating peptides, and cell-mediated delivery. |
| doi_str_mv | 10.2147/DDDT.S79592 |
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The existence of the blood-brain barrier (BBB) restricts the delivery of therapeutic molecules into the brain and offers the clinical efficacy of many pharmaceuticals that have been demonstrated to be effective for other kinds of tumors. This challenge emphasizes the need to be able to deliver drugs effectively across the BBB to reach the brain parenchyma. Enhancement of the permeability of the BBB and being able to transport drugs across it has been shown to be a promising strategy to improve drug absorption and treatment efficacy. This review highlights the innovative technologies that have been introduced to enhance the permeability of the BBB and to obtain an optimal distribution and concentration of drugs in the brain to treat gliomas, such as nanotechniques, hyperthermia techniques, receptor-mediated transport, cell-penetrating peptides, and cell-mediated delivery.</description><identifier>ISSN: 1177-8881</identifier><identifier>EISSN: 1177-8881</identifier><identifier>DOI: 10.2147/DDDT.S79592</identifier><identifier>PMID: 25926719</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - therapeutic use ; Bioavailability ; Blood ; Blood-brain barrier ; Blood-Brain Barrier - drug effects ; Brain ; Brain cancer ; Brain Neoplasms - drug therapy ; Brain tumors ; Cancer therapies ; Cell adhesion & migration ; cell-mediated delivery ; cell-penetrating peptides ; Chemotherapy ; Chinese medicine ; Drug delivery ; Drug delivery systems ; Drug Delivery Systems - adverse effects ; Drug therapy ; Drugs ; Gene therapy ; Glioma ; Glioma - drug therapy ; Gliomas ; Humans ; Hyperthermia ; Lethality ; Membrane permeability ; Nanoparticles ; Nanotechnology ; Parenchyma ; Peptides ; Permeability ; Permeability - drug effects ; Physiological aspects ; Prognosis ; Radiation therapy ; receptor-mediated transport ; Review ; Stem cells ; Surgery ; Testing ; Transport ; Tumors ; Vehicles</subject><ispartof>Drug design, development and therapy, 2015-01, Vol.9, p.2089-2100</ispartof><rights>COPYRIGHT 2015 Dove Medical Press Limited</rights><rights>2015. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-d73afe8f7293254d617d89132db3a76983ea9ed1381fbd35efa5df9715a0c8143</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403597/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403597/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,3849,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25926719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Fang</creatorcontrib><creatorcontrib>Xu, Chun-Lei</creatorcontrib><creatorcontrib>Liu, Chun-Mei</creatorcontrib><title>Drug delivery strategies to enhance the permeability of the blood-brain barrier for treatment of glioma</title><title>Drug design, development and therapy</title><addtitle>Drug Des Devel Ther</addtitle><description>Gliomas are amongst the most insidious and destructive types of brain cancer and are associated with a poor prognosis, frequent recurrences, and extremely high lethality despite combination treatment of surgery, radiotherapy, and chemotherapy. The existence of the blood-brain barrier (BBB) restricts the delivery of therapeutic molecules into the brain and offers the clinical efficacy of many pharmaceuticals that have been demonstrated to be effective for other kinds of tumors. This challenge emphasizes the need to be able to deliver drugs effectively across the BBB to reach the brain parenchyma. Enhancement of the permeability of the BBB and being able to transport drugs across it has been shown to be a promising strategy to improve drug absorption and treatment efficacy. This review highlights the innovative technologies that have been introduced to enhance the permeability of the BBB and to obtain an optimal distribution and concentration of drugs in the brain to treat gliomas, such as nanotechniques, hyperthermia techniques, receptor-mediated transport, cell-penetrating peptides, and cell-mediated delivery.</description><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Bioavailability</subject><subject>Blood</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain tumors</subject><subject>Cancer therapies</subject><subject>Cell adhesion & migration</subject><subject>cell-mediated delivery</subject><subject>cell-penetrating peptides</subject><subject>Chemotherapy</subject><subject>Chinese medicine</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - adverse effects</subject><subject>Drug therapy</subject><subject>Drugs</subject><subject>Gene therapy</subject><subject>Glioma</subject><subject>Glioma - drug therapy</subject><subject>Gliomas</subject><subject>Humans</subject><subject>Hyperthermia</subject><subject>Lethality</subject><subject>Membrane permeability</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Parenchyma</subject><subject>Peptides</subject><subject>Permeability</subject><subject>Permeability - drug effects</subject><subject>Physiological aspects</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>receptor-mediated transport</subject><subject>Review</subject><subject>Stem cells</subject><subject>Surgery</subject><subject>Testing</subject><subject>Transport</subject><subject>Tumors</subject><subject>Vehicles</subject><issn>1177-8881</issn><issn>1177-8881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNks1rFDEYxgdRbK2evMuAIILsmq-ZJBehdP2CggfrOWQmb2ZTMpM1ySzsf2_Wre2ueJAcEt78nifJm6eqXmK0JJjx96vV6mb5nctGkkfVOcacL4QQ-PHR-qx6ltItQi1tCXpanZHCthzL82pYxXmoDXi3hbirU446w-Ag1TnUMK311EOd11BvII6gO-dd3tXB_q51PgSz6KJ2U93pGB3E2oZY5wg6jzDlPTh4F0b9vHpitU_w4m6-qH58-nhz9WVx_e3z16vL60XfMJYXhlNtQVhOJCUNMy3mRkhMiemo5q0UFLQEg6nAtjO0AasbYyXHjUa9wIxeVB8Ovpu5G8H05RJRe7WJbtRxp4J26nRncms1hK1iDNFG8mKADgYmbGETIaUT8UO1D6MimFBZJG_vzozh5wwpq9GlHrzXE4Q5KdxK3CIsOPkPVCDGpGybgr7-C70Nc5xK8xQhpG0kw4g_UIP2oNxkQ3lVvzdVl4wJ3PCWokIt_0GVYWB0fZjAulI_Ebw5EqxB-7xOwc_ZhSmdgu8OYB9DShHsfbcwUvt4qn081SGehX51_Dv37J880l-f9t_Q</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Zhang, Fang</creator><creator>Xu, Chun-Lei</creator><creator>Liu, Chun-Mei</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Press</general><general>Dove Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Drug delivery strategies to enhance the permeability of the blood-brain barrier for treatment of glioma</title><author>Zhang, Fang ; Xu, Chun-Lei ; Liu, Chun-Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-d73afe8f7293254d617d89132db3a76983ea9ed1381fbd35efa5df9715a0c8143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Bioavailability</topic><topic>Blood</topic><topic>Blood-brain barrier</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Brain</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Brain tumors</topic><topic>Cancer therapies</topic><topic>Cell adhesion & migration</topic><topic>cell-mediated delivery</topic><topic>cell-penetrating peptides</topic><topic>Chemotherapy</topic><topic>Chinese medicine</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Drug Delivery Systems - adverse effects</topic><topic>Drug therapy</topic><topic>Drugs</topic><topic>Gene therapy</topic><topic>Glioma</topic><topic>Glioma - drug therapy</topic><topic>Gliomas</topic><topic>Humans</topic><topic>Hyperthermia</topic><topic>Lethality</topic><topic>Membrane permeability</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Parenchyma</topic><topic>Peptides</topic><topic>Permeability</topic><topic>Permeability - drug effects</topic><topic>Physiological aspects</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>receptor-mediated transport</topic><topic>Review</topic><topic>Stem cells</topic><topic>Surgery</topic><topic>Testing</topic><topic>Transport</topic><topic>Tumors</topic><topic>Vehicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Fang</creatorcontrib><creatorcontrib>Xu, Chun-Lei</creatorcontrib><creatorcontrib>Liu, Chun-Mei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Drug design, development and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Fang</au><au>Xu, Chun-Lei</au><au>Liu, Chun-Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug delivery strategies to enhance the permeability of the blood-brain barrier for treatment of glioma</atitle><jtitle>Drug design, development and therapy</jtitle><addtitle>Drug Des Devel Ther</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>9</volume><spage>2089</spage><epage>2100</epage><pages>2089-2100</pages><issn>1177-8881</issn><eissn>1177-8881</eissn><abstract>Gliomas are amongst the most insidious and destructive types of brain cancer and are associated with a poor prognosis, frequent recurrences, and extremely high lethality despite combination treatment of surgery, radiotherapy, and chemotherapy. The existence of the blood-brain barrier (BBB) restricts the delivery of therapeutic molecules into the brain and offers the clinical efficacy of many pharmaceuticals that have been demonstrated to be effective for other kinds of tumors. This challenge emphasizes the need to be able to deliver drugs effectively across the BBB to reach the brain parenchyma. Enhancement of the permeability of the BBB and being able to transport drugs across it has been shown to be a promising strategy to improve drug absorption and treatment efficacy. This review highlights the innovative technologies that have been introduced to enhance the permeability of the BBB and to obtain an optimal distribution and concentration of drugs in the brain to treat gliomas, such as nanotechniques, hyperthermia techniques, receptor-mediated transport, cell-penetrating peptides, and cell-mediated delivery.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>25926719</pmid><doi>10.2147/DDDT.S79592</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Drug design, development and therapy, 2015-01, Vol.9, p.2089-2100 |
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| source | Taylor & Francis Open Access; MEDLINE; DOVE Medical Press Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Bioavailability Blood Blood-brain barrier Blood-Brain Barrier - drug effects Brain Brain cancer Brain Neoplasms - drug therapy Brain tumors Cancer therapies Cell adhesion & migration cell-mediated delivery cell-penetrating peptides Chemotherapy Chinese medicine Drug delivery Drug delivery systems Drug Delivery Systems - adverse effects Drug therapy Drugs Gene therapy Glioma Glioma - drug therapy Gliomas Humans Hyperthermia Lethality Membrane permeability Nanoparticles Nanotechnology Parenchyma Peptides Permeability Permeability - drug effects Physiological aspects Prognosis Radiation therapy receptor-mediated transport Review Stem cells Surgery Testing Transport Tumors Vehicles |
| title | Drug delivery strategies to enhance the permeability of the blood-brain barrier for treatment of glioma |
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