Functional analysis of the short isoform of orf virus protein OV20.0

Orf virus (ORFV) OV20.0L is an ortholog of vaccinia virus (VACV) gene E3L. The function of VACV E3 protein as a virulence factor is well studied, but OV20.0 has received less attention. Here we show that like VACV E3L, OV20.0L encodes two proteins, a full-length protein and a shorter form (sh20). Th...

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Veröffentlicht in:	Journal of virology 2015-05, Vol.89 (9), p.4966-4979
Hauptverfasser:	Tseng, Yeu-Yang, Lin, Fong-Yuan, Cheng, Sun-Fang, Tscharke, David, Chulakasian, Songkhla, Chou, Chia-Chi, Liu, Ya-Fen, Chang, Wei-Shan, Wong, Min-Liang, Hsu, Wei-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line Disease Models, Animal DNA - metabolism Ecthyma, Contagious - pathology Ecthyma, Contagious - virology eIF-2 Kinase - antagonists & inhibitors eIF-2 Kinase - metabolism Eukaryotic Initiation Factor-2 - metabolism Humans Mice, Inbred BALB C Molecular Sequence Data Orf virus Orf virus - physiology Phosphorylation Protein Binding Protein Isoforms - metabolism Protein Processing, Post-Translational RNA-Binding Proteins - genetics Sequence Homology, Amino Acid Sindbis virus Vaccinia virus Viral Proteins - genetics Viral Proteins - metabolism Virus-Cell Interactions
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