Expression of a Surface Antigen (MA6) by Peripheral Blood CD34+ Cells Is Correlated with Improved Platelet Engraftment and May Explain Delayed Platelet Engraftment Following Cord Blood Transplantation

CD34 + cell dose provides a measure of hematopoietic tissue that predicts the rate of engraftment upon transplant. It is positively correlated with multiple measures of hematopoietic recovery, including platelet engraftment. Here we identify a subpopulation of CD34 + cells that coexpress a surface a...

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Veröffentlicht in:	Stem cells and development 2015-05, Vol.24 (9), p.166-1072
Hauptverfasser:	Simmons, Paul J., Robinson, Simon N., Munsell, Mark F., Thomas, Michael W., Javni, Jeannie A., Brouard, Nathalie, Zweidler-McKay, Patrick A., Shpall, Elizabeth J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - genetics Antigens, CD34 - metabolism Blood Platelets - cytology Blood Platelets - metabolism Fetal Blood - cytology Fetal Blood - transplantation Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Original Research Reports Platelet Transfusion
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