Cancer spectrum and frequency among children with Noonan, Costello, and cardio-facio-cutaneous syndromes

Background: Somatic mutations affecting components of the Ras-MAPK pathway are a common feature of cancer, whereas germline Ras pathway mutations cause developmental disorders including Noonan, Costello, and cardio-facio-cutaneous syndromes. These ‘RASopathies’ also represent cancer-prone syndromes,...

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Veröffentlicht in:	British journal of cancer 2015-04, Vol.112 (8), p.1392-1397
Hauptverfasser:	Kratz, C P, Franke, L, Peters, H, Kohlschmidt, N, Kazmierczak, B, Finckh, U, Bier, A, Eichhorn, B, Blank, C, Kraus, C, Kohlhase, J, Pauli, S, Wildhardt, G, Kutsche, K, Auber, B, Christmann, A, Bachmann, N, Mitter, D, Cremer, F W, Mayer, K, Daumer-Haas, C, Nevinny-Stickel-Hinzpeter, C, Oeffner, F, Schlüter, G, Gencik, M, Überlacker, B, Lissewski, C, Schanze, I, Greene, M H, Spix, C, Zenker, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/86 692/420/2489/68 692/499 692/699/67/2332 Adolescent Biomedical and Life Sciences Biomedicine Cancer Research Child Child, Preschool Costello Syndrome - genetics Costello Syndrome - pathology Drug Resistance Ectodermal Dysplasia - genetics Ectodermal Dysplasia - pathology Epidemiology Facies Failure to Thrive - genetics Failure to Thrive - pathology Female Germ-Line Mutation Germany - epidemiology Heart Defects, Congenital - genetics Heart Defects, Congenital - pathology Humans Infant Male Molecular Diagnostics Molecular Medicine Neoplasms - epidemiology Neoplasms - etiology Neoplasms - pathology Noonan Syndrome - genetics Noonan Syndrome - pathology Oncology ras Proteins - genetics Registries Risk Factors Signal Transduction
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