A liaR Deletion Restores Susceptibility to Daptomycin and Antimicrobial Peptides in Multidrug-Resistant Enterococcus faecalis

Daptomycin is a lipopeptide antibiotic that is used clinically against many gram-positive bacterial pathogens and is considered a key frontline bactericidal antibiotic to treat multidrug-resistant enterococci. Emergence of daptomycin resistance during therapy of serious enterococcal infections is a...

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Veröffentlicht in:	The Journal of infectious diseases 2015-04, Vol.211 (8), p.1317-1325
Hauptverfasser:	Reyes, Jinnethe, Panesso, Diana, Tran, True T., Mishra, Nagendra N., Cruz, Melissa R., Munita, Jose M., Singh, Kavindra V., Yeaman, Michael R., Murray, Barbara E., Shamoo, Yousif, Garsin, Danielle, Bayer, Arnold S., Arias, Cesar A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anti-Infective Agents - pharmacology BACTERIA Bacterial Proteins - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans - microbiology Cardiolipins - metabolism Cell Membrane - metabolism Cell Membrane - microbiology Daptomycin - pharmacology Drug Resistance, Multiple, Bacterial - genetics Enterococcus faecalis - drug effects Enterococcus faecalis - genetics Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - metabolism Gram-Positive Bacterial Infections - microbiology Major and Brief Reports Microbial Sensitivity Tests - methods Peptides - pharmacology Sequence Deletion - genetics
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