The p110α isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival

Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylates the 3′OH of the inositol ring of phosphoinositides (PIs). They are responsible for coordinating a diverse range of cellular functions. Class IA PI3K is a heterodimeric protein composed of a regulatory p85 and a cata...

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Veröffentlicht in:	Biochimie 2015-05, Vol.112, p.35-40
Hauptverfasser:	Rajala, Raju V.S., Ranjo-Bishop, Michelle, Wang, Yuhong, Rajala, Ammaji, Anderson, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - physiology Class I Phosphatidylinositol 3-Kinases - genetics Class I Phosphatidylinositol 3-Kinases - metabolism color vision Cone photoreceptors cones (retina) Cre-loxP system inositols lipids Mice Mice, Knockout phosphatidylinositol 3-kinase Phosphoinositide 3-kinases Phosphoinositides Retina Retinal Cone Photoreceptor Cells - cytology Retinal Cone Photoreceptor Cells - enzymology Signal Transduction - physiology Vision
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