Psoriasis and Cardiometabolic Traits: Modest Association but Distinct Genetic Architectures
Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,...
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| Veröffentlicht in: | Journal of investigative dermatology 2015-05, Vol.135 (5), p.1283-1293 |
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| creator | Koch, Manja Baurecht, Hansjörg Ried, Janina S Rodriguez, Elke Schlesinger, Sabrina Volks, Natalie Gieger, Christian Rückert, Ina-Maria Heinrich, Luise Willenborg, Christina Smith, Catherine Peters, Annette Thorand, Barbara Koenig, Wolfgang Lamina, Claudia Jansen, Henning Kronenberg, Florian Seissler, Jochen Thiery, Joachim Rathmann, Wolfgang Schunkert, Heribert Erdmann, Jeanette Barker, Jonathan Nair, Rajan P. Tsoi, Lam C. Elder, James T. Mrowietz, Ulrich Weichenthal, Michael Mucha, Sören Schreiber, Stefan Franke, Andre Schmitt, Jochen Lieb, Wolfgang Weidinger, Stephan |
| description | Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95% confidence interval CI=1.26–4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03–4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95% CI=1.08–1.14) and MI (RR=1.14; 95% CI=1.06–1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct. |
| doi_str_mv | 10.1038/jid.2015.8 |
| format | Article |
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We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95% confidence interval CI=1.26–4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03–4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95% CI=1.08–1.14) and MI (RR=1.14; 95% CI=1.06–1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1038/jid.2015.8</identifier><identifier>PMID: 25599394</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Case-Control Studies ; Cohort Studies ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - genetics ; Female ; Genetic Predisposition to Disease - genetics ; Genotype ; Germany ; Humans ; Incidence ; Insurance Benefits - statistics & numerical data ; Insurance, Health - statistics & numerical data ; Longitudinal Studies ; Male ; Middle Aged ; Myocardial Infarction - epidemiology ; Myocardial Infarction - genetics ; Polymorphism, Single Nucleotide - genetics ; Prospective Studies ; Psoriasis - complications ; Psoriasis - genetics ; Risk Factors ; Severity of Illness Index</subject><ispartof>Journal of investigative dermatology, 2015-05, Vol.135 (5), p.1283-1293</ispartof><rights>2015 The Society for Investigative Dermatology, Inc</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-f058f7fa36822b5d6ecf46ccf25a81d3beaa459e155928d863bbab14c506da03</citedby><cites>FETCH-LOGICAL-c559t-f058f7fa36822b5d6ecf46ccf25a81d3beaa459e155928d863bbab14c506da03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25599394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koch, Manja</creatorcontrib><creatorcontrib>Baurecht, Hansjörg</creatorcontrib><creatorcontrib>Ried, Janina S</creatorcontrib><creatorcontrib>Rodriguez, Elke</creatorcontrib><creatorcontrib>Schlesinger, Sabrina</creatorcontrib><creatorcontrib>Volks, Natalie</creatorcontrib><creatorcontrib>Gieger, Christian</creatorcontrib><creatorcontrib>Rückert, Ina-Maria</creatorcontrib><creatorcontrib>Heinrich, Luise</creatorcontrib><creatorcontrib>Willenborg, Christina</creatorcontrib><creatorcontrib>Smith, Catherine</creatorcontrib><creatorcontrib>Peters, Annette</creatorcontrib><creatorcontrib>Thorand, Barbara</creatorcontrib><creatorcontrib>Koenig, Wolfgang</creatorcontrib><creatorcontrib>Lamina, Claudia</creatorcontrib><creatorcontrib>Jansen, Henning</creatorcontrib><creatorcontrib>Kronenberg, Florian</creatorcontrib><creatorcontrib>Seissler, Jochen</creatorcontrib><creatorcontrib>Thiery, Joachim</creatorcontrib><creatorcontrib>Rathmann, Wolfgang</creatorcontrib><creatorcontrib>Schunkert, Heribert</creatorcontrib><creatorcontrib>Erdmann, Jeanette</creatorcontrib><creatorcontrib>Barker, Jonathan</creatorcontrib><creatorcontrib>Nair, Rajan P.</creatorcontrib><creatorcontrib>Tsoi, Lam C.</creatorcontrib><creatorcontrib>Elder, James T.</creatorcontrib><creatorcontrib>Mrowietz, Ulrich</creatorcontrib><creatorcontrib>Weichenthal, Michael</creatorcontrib><creatorcontrib>Mucha, Sören</creatorcontrib><creatorcontrib>Schreiber, Stefan</creatorcontrib><creatorcontrib>Franke, Andre</creatorcontrib><creatorcontrib>Schmitt, Jochen</creatorcontrib><creatorcontrib>Lieb, Wolfgang</creatorcontrib><creatorcontrib>Weidinger, Stephan</creatorcontrib><title>Psoriasis and Cardiometabolic Traits: Modest Association but Distinct Genetic Architectures</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95% confidence interval CI=1.26–4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03–4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95% CI=1.08–1.14) and MI (RR=1.14; 95% CI=1.06–1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.</description><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Germany</subject><subject>Humans</subject><subject>Incidence</subject><subject>Insurance Benefits - statistics & numerical data</subject><subject>Insurance, Health - statistics & numerical data</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - genetics</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Prospective Studies</subject><subject>Psoriasis - complications</subject><subject>Psoriasis - genetics</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LAzEQhoMoWqsXf4DsWdiaZJNt6kEo9RMUPfQgeAjZZNZOaTclSQX_vSlVUfA0h3nmnZmHkBNGB4xW6nyObsApkwO1Q3pM8qpkQzHcJT1KOS855S8H5DDGOaWsFlLtkwMu5WhUjUSPvD5HH9BEjIXpXDExwaFfQjKNX6AtpsFgihfFo3cQUzGO0Vs0CX1XNOtUXGFM2NlU3EIHKfPjYGeYwKZ1gHhE9lqziHD8VftkenM9ndyVD0-395PxQ2nzGalsqVTtsDVVrThvpKvBtqK2tuXSKOaqBowRcgQs01w5VVdNYxomrKS1M7Tqk8tt7GrdLMFZ6FIwC70KuDThQ3uD-m-nw5l-8-9aCMoZG-aAs22ADT7GAO3PLKN6Y1hnw3pjWKsMn_7e9oN-K82A2AKQX35HCDpahM6Cw5DFaOfxv9xPK3KMVw</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Koch, Manja</creator><creator>Baurecht, Hansjörg</creator><creator>Ried, Janina S</creator><creator>Rodriguez, Elke</creator><creator>Schlesinger, Sabrina</creator><creator>Volks, Natalie</creator><creator>Gieger, Christian</creator><creator>Rückert, Ina-Maria</creator><creator>Heinrich, Luise</creator><creator>Willenborg, Christina</creator><creator>Smith, Catherine</creator><creator>Peters, Annette</creator><creator>Thorand, Barbara</creator><creator>Koenig, Wolfgang</creator><creator>Lamina, Claudia</creator><creator>Jansen, Henning</creator><creator>Kronenberg, Florian</creator><creator>Seissler, Jochen</creator><creator>Thiery, Joachim</creator><creator>Rathmann, Wolfgang</creator><creator>Schunkert, Heribert</creator><creator>Erdmann, Jeanette</creator><creator>Barker, Jonathan</creator><creator>Nair, Rajan P.</creator><creator>Tsoi, Lam C.</creator><creator>Elder, James T.</creator><creator>Mrowietz, Ulrich</creator><creator>Weichenthal, Michael</creator><creator>Mucha, Sören</creator><creator>Schreiber, Stefan</creator><creator>Franke, Andre</creator><creator>Schmitt, Jochen</creator><creator>Lieb, Wolfgang</creator><creator>Weidinger, Stephan</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20150501</creationdate><title>Psoriasis and Cardiometabolic Traits: Modest Association but Distinct Genetic Architectures</title><author>Koch, Manja ; Baurecht, Hansjörg ; Ried, Janina S ; Rodriguez, Elke ; Schlesinger, Sabrina ; Volks, Natalie ; Gieger, Christian ; Rückert, Ina-Maria ; Heinrich, Luise ; Willenborg, Christina ; Smith, Catherine ; Peters, Annette ; Thorand, Barbara ; Koenig, Wolfgang ; Lamina, Claudia ; Jansen, Henning ; Kronenberg, Florian ; Seissler, Jochen ; Thiery, Joachim ; Rathmann, Wolfgang ; Schunkert, Heribert ; Erdmann, Jeanette ; Barker, Jonathan ; Nair, Rajan P. ; Tsoi, Lam C. ; Elder, James T. ; Mrowietz, Ulrich ; Weichenthal, Michael ; Mucha, Sören ; Schreiber, Stefan ; Franke, Andre ; Schmitt, Jochen ; Lieb, Wolfgang ; Weidinger, Stephan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-f058f7fa36822b5d6ecf46ccf25a81d3beaa459e155928d863bbab14c506da03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - 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We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95% confidence interval CI=1.26–4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03–4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95% CI=1.08–1.14) and MI (RR=1.14; 95% CI=1.06–1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25599394</pmid><doi>10.1038/jid.2015.8</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of investigative dermatology, 2015-05, Vol.135 (5), p.1283-1293 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Case-Control Studies Cohort Studies Cross-Sectional Studies Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Female Genetic Predisposition to Disease - genetics Genotype Germany Humans Incidence Insurance Benefits - statistics & numerical data Insurance, Health - statistics & numerical data Longitudinal Studies Male Middle Aged Myocardial Infarction - epidemiology Myocardial Infarction - genetics Polymorphism, Single Nucleotide - genetics Prospective Studies Psoriasis - complications Psoriasis - genetics Risk Factors Severity of Illness Index |
| title | Psoriasis and Cardiometabolic Traits: Modest Association but Distinct Genetic Architectures |
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