Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) Stability Contributes to YM155 Resistance in Human Gastric Cancer Cells

YM155, which blocks the expression of survivin, a member of the inhibitor of apoptosis (IAP) family, induces cell death in a variety of cancer types, including prostate, bladder, breast, leukemia, and non-small lung cancer. However, the mechanism underlying gastric cancer susceptibility and resistan...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2015-04, Vol.290 (16), p.9974-9985
Hauptverfasser:	Jung, Soo-A, Park, Yong-Man, Hong, Seung-Woo, Moon, Jai-Hee, Shin, Jae-Sik, Lee, Ha-Reum, Ha, Seung-Hee, Lee, Dae-Hee, Kim, Jeong Hee, Kim, Seung-Mi, Kim, Jeong Eun, Kim, Kyu-pyo, Hong, Yong Sang, Choi, Eun Kyung, Lee, Jung Shin, Jin, Dong-Hoon, Kim, TaeWon
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer Drug Antineoplastic Agents - pharmacology Apoptosis Cell Death - drug effects Cell Line, Tumor Drug Resistance, Neoplasm - genetics Gastric Cancer Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology Gene Expression Regulation, Neoplastic Humans Imidazoles - pharmacology Inhibitor of Apoptosis Proteins - antagonists & inhibitors Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Naphthoquinones - pharmacology Protein Binding Protein Stability Protein Synthesis and Degradation Proteolysis RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction Survivin Ubiquitination Ubiquitylation (Ubiquitination) YM155, cIAP1
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!