Type I Interferon Controls Propagation of Long Interspersed Element-1

Type I interferons (IFN) including IFNα and IFNβ are critical for the cellular defense against viruses. Here we report that increased levels of IFNβ were found in testes from mice deficient in MOV10L1, a germ cell-specific RNA helicase that plays a key role in limiting the propagation of retrotransp...

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Veröffentlicht in:	The Journal of biological chemistry 2015-04, Vol.290 (16), p.10191-10199
Hauptverfasser:	Yu, Qiujing, Carbone, Christopher J., Katlinskaya, Yuliya V., Zheng, Hui, Zheng, Ke, Luo, Mengcheng, Wang, P. Jeremy, Greenberg, Roger A., Fuchs, Serge Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA damage Embryo, Mammalian Fibroblasts - cytology Fibroblasts - immunology Fibroblasts - metabolism Gene Expression Regulation Genomic Instability HeLa Cells Humans interferon Interferon-alpha - genetics Interferon-alpha - immunology Interferon-alpha - metabolism Interferon-beta - genetics Interferon-beta - immunology Interferon-beta - metabolism LINE-1 Long Interspersed Nucleotide Elements Male Mice Mice, Inbred C57BL Mice, Knockout NIH 3T3 Cells Primary Cell Culture radiation receptor Receptor, Interferon alpha-beta - deficiency Receptor, Interferon alpha-beta - genetics Receptor, Interferon alpha-beta - immunology retrotransposon RNA Helicases - deficiency RNA Helicases - genetics RNA Helicases - immunology Signal Transduction signaling Testis - cytology Testis - immunology Testis - metabolism
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