Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation
We present a primary example of a cell surface modified with a synergistic combination of agonists to tune immune stimulation. A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. The immune-stimulat...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2013-10, Vol.49 (83), p.9618-9620 |
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| container_end_page | 9620 |
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| container_issue | 83 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 49 |
| creator | Tom, Janine K Mancini, Rock J Esser-Kahn, Aaron P |
| description | We present a primary example of a cell surface modified with a synergistic combination of agonists to tune immune stimulation. A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. The immune-stimulating constructs provided greater stimulation of NF-κB in a model cell line and bone marrow-derived dendritic cells than the components unconjugated in solution. |
| doi_str_mv | 10.1039/c3cc45468a |
| format | Article |
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A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. 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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2013-10, Vol.49 (83), p.9618-9620 |
| issn | 1359-7345 1364-548X 1364-548X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4399865 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | agonists Animals Biotechnology Bones Cancer Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - immunology Cell Line, Tumor cell lines chemical bonding chemical communication chemical reactions Covalence dendritic cells Immune systems Lipopolysaccharides - chemistry Lipopolysaccharides - pharmacology lipoteichoic acids lung neoplasms Mathematical models NF-kappa B - immunology oligodeoxyribonucleotides Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - pharmacology Proteins Stimulation Teichoic Acids - chemistry Teichoic Acids - pharmacology Toll-like receptors Toll-Like Receptors - agonists Toll-Like Receptors - immunology transcription factor NF-kappa B |
| title | Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation |
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