Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation

We present a primary example of a cell surface modified with a synergistic combination of agonists to tune immune stimulation. A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. The immune-stimulat...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-10, Vol.49 (83), p.9618-9620
Hauptverfasser:	Tom, Janine K, Mancini, Rock J, Esser-Kahn, Aaron P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotechnology Bones Cancer Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - immunology Cell Line, Tumor Covalence Immune systems Lipopolysaccharides - chemistry Lipopolysaccharides - pharmacology Mathematical models NF-kappa B - immunology Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - pharmacology Proteins Stimulation Teichoic Acids - chemistry Teichoic Acids - pharmacology Toll-Like Receptors - agonists Toll-Like Receptors - immunology
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Beschreibung
Zusammenfassung:	We present a primary example of a cell surface modified with a synergistic combination of agonists to tune immune stimulation. A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. The immune-stimulating constructs provided greater stimulation of NF-κB in a model cell line and bone marrow-derived dendritic cells than the components unconjugated in solution.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c3cc45468a