Estrogen and Estrogen Receptor-α-Mediated Transrepression of Bile Salt Export Pump

Among diseases unique to pregnancy, intrahepatic cholestasis of pregnancy is the most prevalent disorder with elevated serum bile acid levels. We have previously shown that estrogen 17β-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-α...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2015-04, Vol.29 (4), p.613-626
Hauptverfasser:	Chen, Yuan, Vasilenko, Alex, Song, Xiulong, Valanejad, Leila, Verma, Ruchi, You, Sangmin, Yan, Bingfang, Shiffka, Stephanie, Hargreaves, Leeza, Nadolny, Christina, Deng, Ruitang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Subfamily B Member 11 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Cell Line, Tumor Estradiol - pharmacology Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Humans Mice Original Research Promoter Regions, Genetic Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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