TAZ regulates cell proliferation and epithelial–mesenchymal transition of human hepatocellular carcinoma

The transcriptional coactivator with PDZ binding motif (TAZ) has been reported to be one of the nuclear effectors of Hippo‐related pathways. TAZ is expressed in many primary tumors and could regulate many biological processes. However, little is known about the role of TAZ in hepatocellular carcinom...

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Veröffentlicht in:	Cancer science 2015-02, Vol.106 (2), p.151-159
Hauptverfasser:	Xiao, Heng, Jiang, Ning, Zhou, Baoyong, Liu, Qiang, Du, Chengyou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - genetics Breast cancer Cadherins - genetics Cancer stem cell Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Epithelial-Mesenchymal Transition - genetics epithelial–mesenchymal transition (EMT) Gene expression Hepatocellular carcinoma Homeodomain Proteins human hepatocellular carcinoma (HCC) Humans Immunoglobulins Intracellular Signaling Peptides and Proteins - genetics Invasiveness Laboratory animals Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 9 - genetics Medical prognosis Mesenchyme Metastases Metastasis Mice Nanog Homeobox Protein Oct-4 protein Octamer Transcription Factor-3 Original Patients Proteins Signal Transduction - genetics Snail Family Transcription Factors SOXB1 Transcription Factors Stem cells Stem Cells - metabolism Survival Rate TAZ Transcription Tumorigenicity Tumors Up-Regulation - genetics Vimentin Vimentin - genetics Xenografts
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