Reduced availability of voltage‐gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells

Key points Mouse chromaffin cells (MCCs) of the adrenal medulla possess fast‐inactivating Nav channels whose availability alters spontaneous action potential firing patterns and the Ca2+‐dependent secretion of catecholamines. Here, we report MCCs expressing large densities of neuronal fast‐inactivat...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of physiology 2015-02, Vol.593 (4), p.905-927
Hauptverfasser:	Vandael, David H. F., Ottaviani, Matteo M., Legros, Christian, Lefort, Claudie, Guérineau, Nathalie C., Allio, Arianna, Carabelli, Valentina, Carbone, Emilio
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Adrenal Medulla - physiology Animals Catecholamines - metabolism Chromaffin Cells - drug effects Chromaffin Cells - metabolism Chromaffin Cells - physiology Life Sciences Male Mice, Inbred C57BL Neurons and Cognition Neuroscience: Cellular/Molecular Sodium Channel Blockers - pharmacology Tetrodotoxin - pharmacology Voltage-Gated Sodium Channels - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!