Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients
In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ...
Gespeichert in:
| Veröffentlicht in: | The open dentistry journal 2015-01, Vol.9 (1), p.120-124 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 124 |
|---|---|
| container_issue | 1 |
| container_start_page | 120 |
| container_title | The open dentistry journal |
| container_volume | 9 |
| creator | Naganawa, Kosuke Takayama, Eiji Adachi, Makoto Mitsudo, Kenji Iida, Masaki Kamiya-Mizuno, Masako Kawaki, Harumi Ichinose, Masao Motohashi, Masayuki Muramatsu, Yasunori Tohnai, Iwai Sumitomo, Shin-Ichiro Shikimori, Michio Kondoh, Nobuo |
| description | In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs. |
| doi_str_mv | 10.2174/1874210601509010120 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4397950</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1674686891</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-ea9b08a23ca4186c691f5a5f66a03cbedf3884dc2b9ecbcd0a523c4fc4888c363</originalsourceid><addsrcrecordid>eNptUV1r3DAQFKWl-eovKBQ99sXNypJl-aXQHkkTCOSgzbNYy9JFrS1dJDsQyI-vjktCCn1a7Wh2Zpch5CODLzVrxSlTragZSGANdMCA1fCGHO7Qage_ffU-IEc5_waQHJR8Tw7qRnUcanZIHtcpDovxYUNXuMXej372NtPo6GWYbXI2xVBtcJqQYhj24GiXPz5UDKgPdG2T397ahCP9PsY4UJfiRK93_c-7Bae4ZLqy41j0U_GJRWiNxSPM-YS8czhm--GpHpOb87Nfq4vq6vrH5erbVWVEy-bKYteDwpobFExJIzvmGmyclAjc9HZwXCkxmLrvrOnNANgUrnBGKKUMl_yYfN3rbpd-soMp3mU9vU1-wvSgI3r970_wt3oT77XgXds1UAQ-PwmkeLfYPOvJZ1OOwmDLfZrJVkglVccKle-pJsWck3UvNgz0Ljf9n9zK1KfXG77MPAfF_wIjmZXk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1674686891</pqid></control><display><type>article</type><title>Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Naganawa, Kosuke ; Takayama, Eiji ; Adachi, Makoto ; Mitsudo, Kenji ; Iida, Masaki ; Kamiya-Mizuno, Masako ; Kawaki, Harumi ; Ichinose, Masao ; Motohashi, Masayuki ; Muramatsu, Yasunori ; Tohnai, Iwai ; Sumitomo, Shin-Ichiro ; Shikimori, Michio ; Kondoh, Nobuo</creator><creatorcontrib>Naganawa, Kosuke ; Takayama, Eiji ; Adachi, Makoto ; Mitsudo, Kenji ; Iida, Masaki ; Kamiya-Mizuno, Masako ; Kawaki, Harumi ; Ichinose, Masao ; Motohashi, Masayuki ; Muramatsu, Yasunori ; Tohnai, Iwai ; Sumitomo, Shin-Ichiro ; Shikimori, Michio ; Kondoh, Nobuo</creatorcontrib><description>In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.</description><identifier>ISSN: 1874-2106</identifier><identifier>EISSN: 1874-2106</identifier><identifier>DOI: 10.2174/1874210601509010120</identifier><identifier>PMID: 25893021</identifier><language>eng</language><publisher>United Arab Emirates: Bentham Open</publisher><ispartof>The open dentistry journal, 2015-01, Vol.9 (1), p.120-124</ispartof><rights>Naganawa ; Licensee 2015 Naganawa</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-ea9b08a23ca4186c691f5a5f66a03cbedf3884dc2b9ecbcd0a523c4fc4888c363</citedby><cites>FETCH-LOGICAL-c471t-ea9b08a23ca4186c691f5a5f66a03cbedf3884dc2b9ecbcd0a523c4fc4888c363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397950/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397950/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25893021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naganawa, Kosuke</creatorcontrib><creatorcontrib>Takayama, Eiji</creatorcontrib><creatorcontrib>Adachi, Makoto</creatorcontrib><creatorcontrib>Mitsudo, Kenji</creatorcontrib><creatorcontrib>Iida, Masaki</creatorcontrib><creatorcontrib>Kamiya-Mizuno, Masako</creatorcontrib><creatorcontrib>Kawaki, Harumi</creatorcontrib><creatorcontrib>Ichinose, Masao</creatorcontrib><creatorcontrib>Motohashi, Masayuki</creatorcontrib><creatorcontrib>Muramatsu, Yasunori</creatorcontrib><creatorcontrib>Tohnai, Iwai</creatorcontrib><creatorcontrib>Sumitomo, Shin-Ichiro</creatorcontrib><creatorcontrib>Shikimori, Michio</creatorcontrib><creatorcontrib>Kondoh, Nobuo</creatorcontrib><title>Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients</title><title>The open dentistry journal</title><addtitle>Open Dent J</addtitle><description>In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.</description><issn>1874-2106</issn><issn>1874-2106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNptUV1r3DAQFKWl-eovKBQ99sXNypJl-aXQHkkTCOSgzbNYy9JFrS1dJDsQyI-vjktCCn1a7Wh2Zpch5CODLzVrxSlTragZSGANdMCA1fCGHO7Qage_ffU-IEc5_waQHJR8Tw7qRnUcanZIHtcpDovxYUNXuMXej372NtPo6GWYbXI2xVBtcJqQYhj24GiXPz5UDKgPdG2T397ahCP9PsY4UJfiRK93_c-7Bae4ZLqy41j0U_GJRWiNxSPM-YS8czhm--GpHpOb87Nfq4vq6vrH5erbVWVEy-bKYteDwpobFExJIzvmGmyclAjc9HZwXCkxmLrvrOnNANgUrnBGKKUMl_yYfN3rbpd-soMp3mU9vU1-wvSgI3r970_wt3oT77XgXds1UAQ-PwmkeLfYPOvJZ1OOwmDLfZrJVkglVccKle-pJsWck3UvNgz0Ljf9n9zK1KfXG77MPAfF_wIjmZXk</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Naganawa, Kosuke</creator><creator>Takayama, Eiji</creator><creator>Adachi, Makoto</creator><creator>Mitsudo, Kenji</creator><creator>Iida, Masaki</creator><creator>Kamiya-Mizuno, Masako</creator><creator>Kawaki, Harumi</creator><creator>Ichinose, Masao</creator><creator>Motohashi, Masayuki</creator><creator>Muramatsu, Yasunori</creator><creator>Tohnai, Iwai</creator><creator>Sumitomo, Shin-Ichiro</creator><creator>Shikimori, Michio</creator><creator>Kondoh, Nobuo</creator><general>Bentham Open</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients</title><author>Naganawa, Kosuke ; Takayama, Eiji ; Adachi, Makoto ; Mitsudo, Kenji ; Iida, Masaki ; Kamiya-Mizuno, Masako ; Kawaki, Harumi ; Ichinose, Masao ; Motohashi, Masayuki ; Muramatsu, Yasunori ; Tohnai, Iwai ; Sumitomo, Shin-Ichiro ; Shikimori, Michio ; Kondoh, Nobuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-ea9b08a23ca4186c691f5a5f66a03cbedf3884dc2b9ecbcd0a523c4fc4888c363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naganawa, Kosuke</creatorcontrib><creatorcontrib>Takayama, Eiji</creatorcontrib><creatorcontrib>Adachi, Makoto</creatorcontrib><creatorcontrib>Mitsudo, Kenji</creatorcontrib><creatorcontrib>Iida, Masaki</creatorcontrib><creatorcontrib>Kamiya-Mizuno, Masako</creatorcontrib><creatorcontrib>Kawaki, Harumi</creatorcontrib><creatorcontrib>Ichinose, Masao</creatorcontrib><creatorcontrib>Motohashi, Masayuki</creatorcontrib><creatorcontrib>Muramatsu, Yasunori</creatorcontrib><creatorcontrib>Tohnai, Iwai</creatorcontrib><creatorcontrib>Sumitomo, Shin-Ichiro</creatorcontrib><creatorcontrib>Shikimori, Michio</creatorcontrib><creatorcontrib>Kondoh, Nobuo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The open dentistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naganawa, Kosuke</au><au>Takayama, Eiji</au><au>Adachi, Makoto</au><au>Mitsudo, Kenji</au><au>Iida, Masaki</au><au>Kamiya-Mizuno, Masako</au><au>Kawaki, Harumi</au><au>Ichinose, Masao</au><au>Motohashi, Masayuki</au><au>Muramatsu, Yasunori</au><au>Tohnai, Iwai</au><au>Sumitomo, Shin-Ichiro</au><au>Shikimori, Michio</au><au>Kondoh, Nobuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients</atitle><jtitle>The open dentistry journal</jtitle><addtitle>Open Dent J</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>9</volume><issue>1</issue><spage>120</spage><epage>124</epage><pages>120-124</pages><issn>1874-2106</issn><eissn>1874-2106</eissn><abstract>In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.</abstract><cop>United Arab Emirates</cop><pub>Bentham Open</pub><pmid>25893021</pmid><doi>10.2174/1874210601509010120</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1874-2106 |
| ispartof | The open dentistry journal, 2015-01, Vol.9 (1), p.120-124 |
| issn | 1874-2106 1874-2106 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4397950 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| title | Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T12%3A52%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Producing%20Capabilities%20of%20Interferon-gamma%20and%20Interleukin-10%20in%20Peripheral%20Blood%20from%20Oral%20Squamous%20Cell%20Carcinoma%20Patients&rft.jtitle=The%20open%20dentistry%20journal&rft.au=Naganawa,%20Kosuke&rft.date=2015-01-01&rft.volume=9&rft.issue=1&rft.spage=120&rft.epage=124&rft.pages=120-124&rft.issn=1874-2106&rft.eissn=1874-2106&rft_id=info:doi/10.2174/1874210601509010120&rft_dat=%3Cproquest_pubme%3E1674686891%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1674686891&rft_id=info:pmid/25893021&rfr_iscdi=true |