Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking

Alcohol and nicotine are the two most co-abused drugs in the world. Previous studies have shown that nicotine can increase alcohol drinking in nondependent rats, yet it is unknown whether nicotine facilitates the transition to alcohol dependence. We tested the hypothesis that chronic nicotine will s...

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Veröffentlicht in:	The Journal of neuroscience 2015-04, Vol.35 (15), p.6241-6253
Hauptverfasser:	Leão, Rodrigo M, Cruz, Fábio C, Vendruscolo, Leandro F, de Guglielmo, Giordano, Logrip, Marian L, Planeta, Cleopatra S, Hope, Bruce T, Koob, George F, George, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking - physiopathology Animals Brain - metabolism Brain - pathology Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Central Nervous System Depressants - administration & dosage Compulsive Behavior - complications Conditioning, Operant - drug effects Disease Models, Animal Ethanol - administration & dosage Glutamate Decarboxylase - metabolism Male Nicotine - adverse effects Nicotinic Agonists - adverse effects Phosphopyruvate Hydratase - metabolism Proto-Oncogene Proteins c-fos - metabolism Quinine - administration & dosage Rats Rats, Wistar Reward Self Administration Time Factors
Online-Zugang:	Volltext
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