Oxidative Stress in Myopia
Myopia affected approximately 1.6 billion people worldwide in 2000, and it is expected to increase to 2.5 billion by 2020. Although optical problems can be corrected by optics or surgical procedures, normal myopia and high myopia are still an unsolved medical problem. They frequently predispose peop...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2015-01, Vol.2015 (2015), p.1-12 |
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| creator | Francisco, Bosch-Morell Salvador, Mérida Amparo, Navea |
| description | Myopia affected approximately 1.6 billion people worldwide in 2000, and it is expected to increase to 2.5 billion by 2020. Although optical problems can be corrected by optics or surgical procedures, normal myopia and high myopia are still an unsolved medical problem. They frequently predispose people who have them to suffer from other eye pathologies: retinal detachment, glaucoma, macular hemorrhage, cataracts, and so on being one of the main causes of visual deterioration and blindness. Genetic and environmental factors have been associated with myopia. Nevertheless, lack of knowledge in the underlying physiopathological molecular mechanisms has not permitted an adequate diagnosis, prevention, or treatment to be found. Nowadays several pieces of evidence indicate that oxidative stress may help explain the altered regulatory pathways in myopia and the appearance of associated eye diseases. On the one hand, oxidative damage associated with hypoxia myopic can alter the neuromodulation that nitric oxide and dopamine have in eye growth. On the other hand, radical superoxide or peroxynitrite production damage retina, vitreous, lens, and so on contributing to the appearance of retinopathies, retinal detachment, cataracts and so on. The objective of this review is to suggest that oxidative stress is one of the key pieces that can help solve this complex eye problem. |
| doi_str_mv | 10.1155/2015/750637 |
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Although optical problems can be corrected by optics or surgical procedures, normal myopia and high myopia are still an unsolved medical problem. They frequently predispose people who have them to suffer from other eye pathologies: retinal detachment, glaucoma, macular hemorrhage, cataracts, and so on being one of the main causes of visual deterioration and blindness. Genetic and environmental factors have been associated with myopia. Nevertheless, lack of knowledge in the underlying physiopathological molecular mechanisms has not permitted an adequate diagnosis, prevention, or treatment to be found. Nowadays several pieces of evidence indicate that oxidative stress may help explain the altered regulatory pathways in myopia and the appearance of associated eye diseases. On the one hand, oxidative damage associated with hypoxia myopic can alter the neuromodulation that nitric oxide and dopamine have in eye growth. On the other hand, radical superoxide or peroxynitrite production damage retina, vitreous, lens, and so on contributing to the appearance of retinopathies, retinal detachment, cataracts and so on. The objective of this review is to suggest that oxidative stress is one of the key pieces that can help solve this complex eye problem.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2015/750637</identifier><identifier>PMID: 25922643</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Apoptosis ; Blindness ; Disease ; Glaucoma ; Growth factors ; Humans ; Myopia ; Myopia - metabolism ; Myopia - pathology ; Nitric Oxide - metabolism ; Oxidative stress ; Oxidative Stress - drug effects ; Population ; Reactive Oxygen Species - metabolism ; Reactive Oxygen Species - toxicity ; Retina - drug effects ; Retina - physiopathology ; Review ; Studies ; Superoxide ; Superoxide Dismutase - metabolism</subject><ispartof>Oxidative medicine and cellular longevity, 2015-01, Vol.2015 (2015), p.1-12</ispartof><rights>Copyright © 2015 Bosch-Morell Francisco et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Bosch-Morell Francisco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Bosch-Morell Francisco et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-2b22d7ac0881e13fcf6713cba411f8168bb9f5970d56a111e7fa76b94bfe2b6e3</citedby><cites>FETCH-LOGICAL-c561t-2b22d7ac0881e13fcf6713cba411f8168bb9f5970d56a111e7fa76b94bfe2b6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397465/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397465/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25922643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Signorini, Cinzia</contributor><creatorcontrib>Francisco, Bosch-Morell</creatorcontrib><creatorcontrib>Salvador, Mérida</creatorcontrib><creatorcontrib>Amparo, Navea</creatorcontrib><title>Oxidative Stress in Myopia</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Myopia affected approximately 1.6 billion people worldwide in 2000, and it is expected to increase to 2.5 billion by 2020. Although optical problems can be corrected by optics or surgical procedures, normal myopia and high myopia are still an unsolved medical problem. They frequently predispose people who have them to suffer from other eye pathologies: retinal detachment, glaucoma, macular hemorrhage, cataracts, and so on being one of the main causes of visual deterioration and blindness. Genetic and environmental factors have been associated with myopia. Nevertheless, lack of knowledge in the underlying physiopathological molecular mechanisms has not permitted an adequate diagnosis, prevention, or treatment to be found. Nowadays several pieces of evidence indicate that oxidative stress may help explain the altered regulatory pathways in myopia and the appearance of associated eye diseases. On the one hand, oxidative damage associated with hypoxia myopic can alter the neuromodulation that nitric oxide and dopamine have in eye growth. On the other hand, radical superoxide or peroxynitrite production damage retina, vitreous, lens, and so on contributing to the appearance of retinopathies, retinal detachment, cataracts and so on. The objective of this review is to suggest that oxidative stress is one of the key pieces that can help solve this complex eye problem.</description><subject>Apoptosis</subject><subject>Blindness</subject><subject>Disease</subject><subject>Glaucoma</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Myopia</subject><subject>Myopia - metabolism</subject><subject>Myopia - pathology</subject><subject>Nitric Oxide - metabolism</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Population</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Reactive Oxygen Species - toxicity</subject><subject>Retina - drug effects</subject><subject>Retina - physiopathology</subject><subject>Review</subject><subject>Studies</subject><subject>Superoxide</subject><subject>Superoxide Dismutase - metabolism</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0UtPAjEUBeDGaETRlTsXhsSN0SC9fdKNCSG-Eg0Ldd10ZlooGWZwOqD8e0tARFeu2qRfTu_NQegE8DUA5x2CgXckx4LKHXQAipE2Vortbu4YN9BhCGMcCWGwjxqEK0IEowfodPDpM1P7uW291JUNoeWL1vOinHpzhPacyYM9Xp9N9HZ3-9p_aD8N7h_7vad2ygXUbZIQkkmT4m4XLFCXOiGBpolhAK4LopskynElccaFAQArnZEiUSxxliTC0ia6WeVOZ8nEZqkt6srkelr5iakWujRe_34p_EgPy7lmVEkmeAy4WAdU5fvMhlpPfEhtnpvClrOg4wwYJJdYRnr-h47LWVXE9TRIrJhQlLEfNTS51b5wZfw3XYbqHuOMSEwViepqpdKqDKGybjMyYL1sRi-b0atmoj7b3nJjv6uI4HIFRr7IzIf_X5qNxDqzheOiXNAvZH6cWg</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Francisco, Bosch-Morell</creator><creator>Salvador, Mérida</creator><creator>Amparo, Navea</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Oxidative Stress in Myopia</title><author>Francisco, Bosch-Morell ; 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Although optical problems can be corrected by optics or surgical procedures, normal myopia and high myopia are still an unsolved medical problem. They frequently predispose people who have them to suffer from other eye pathologies: retinal detachment, glaucoma, macular hemorrhage, cataracts, and so on being one of the main causes of visual deterioration and blindness. Genetic and environmental factors have been associated with myopia. Nevertheless, lack of knowledge in the underlying physiopathological molecular mechanisms has not permitted an adequate diagnosis, prevention, or treatment to be found. Nowadays several pieces of evidence indicate that oxidative stress may help explain the altered regulatory pathways in myopia and the appearance of associated eye diseases. On the one hand, oxidative damage associated with hypoxia myopic can alter the neuromodulation that nitric oxide and dopamine have in eye growth. On the other hand, radical superoxide or peroxynitrite production damage retina, vitreous, lens, and so on contributing to the appearance of retinopathies, retinal detachment, cataracts and so on. The objective of this review is to suggest that oxidative stress is one of the key pieces that can help solve this complex eye problem.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>25922643</pmid><doi>10.1155/2015/750637</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oxidative medicine and cellular longevity, 2015-01, Vol.2015 (2015), p.1-12 |
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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Apoptosis Blindness Disease Glaucoma Growth factors Humans Myopia Myopia - metabolism Myopia - pathology Nitric Oxide - metabolism Oxidative stress Oxidative Stress - drug effects Population Reactive Oxygen Species - metabolism Reactive Oxygen Species - toxicity Retina - drug effects Retina - physiopathology Review Studies Superoxide Superoxide Dismutase - metabolism |
| title | Oxidative Stress in Myopia |
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