Expression and function analysis of indoleamine 2 and 3-dioxygenase in bladder urothelial carcinoma

Indoleamine 2, 3-dioxygenase (IDO) is a rate-limiting enzyme for tryptophan metabolism inducing immune tolerance of tumors. The purpose of this study is to investigate IDO expression and its prognostic significance in bladder urothelial carcinoma (BUC). In this study, immunohistochemical staining fo...

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Veröffentlicht in:	International journal of clinical and experimental pathology 2015-01, Vol.8 (2), p.1768-1775
Hauptverfasser:	Yang, Chenggang, Zhou, Yongchun, Zhang, Lijuan, Jin, Congguo, Li, Mei, Ye, Lijuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Carcinoma - enzymology Carcinoma - genetics Carcinoma - mortality Carcinoma - pathology Carcinoma - surgery Disease Progression Disease-Free Survival Female Humans Immunohistochemistry Indoleamine-Pyrrole 2,3,-Dioxygenase - analysis Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics Kaplan-Meier Estimate Male Middle Aged Neoplasm Grading Neoplasm Staging Original Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Time Factors Urinary Bladder Neoplasms - enzymology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery Urothelium - enzymology Urothelium - pathology Urothelium - surgery Young Adult
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