Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancer

TMSG1, as a novel tumor metastasis suppressor gene, has been demonstrated to closely relate to the metastasis and drug-resistant of breast cancer. However, its molecular mechanism is still unclear. In this study, we explored the effect of small interference RNA (siRNA) targeting TMSG1 on the invasio...

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Veröffentlicht in:	International journal of clinical and experimental pathology 2015-01, Vol.8 (2), p.1312-1320
Hauptverfasser:	Zi, Yuan, Zhao, Wenjian, Zhou, Jun, He, Hanjiang, Xie, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Gene Expression Regulation, Neoplastic Humans Hydrogen-Ion Concentration Matrix Metalloproteinase 2 - metabolism MCF-7 Cells Membrane Proteins - genetics Membrane Proteins - metabolism Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Original RNA Interference RNA, Small Interfering Sphingosine N-Acyltransferase - genetics Sphingosine N-Acyltransferase - metabolism Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Vacuolar Proton-Translocating ATPases - metabolism Wound Healing - genetics
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