Impact of β-lactamase inhibition on the activity of ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

The production of β-lactamases Bla(Mab) and BlaC contributes to β-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from ≥...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2015-05, Vol.59 (5), p.2938-2941
Hauptverfasser:	Dubée, Vincent, Soroka, Daria, Cortes, Mélanie, Lefebvre, Anne-Laure, Gutmann, Laurent, Hugonnet, Jean-Emmanuel, Arthur, Michel, Mainardi, Jean-Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Azabicyclo Compounds - pharmacology Bacteriology beta-Lactamase Inhibitors - pharmacology beta-Lactamases - metabolism Ceftaroline Cephalosporins Cephalosporins - pharmacology Life Sciences Mechanisms of Action: Physiological Effects Microbiology and Parasitology Mycobacterium Mycobacterium - drug effects Mycobacterium - enzymology Mycobacterium abscessus Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - enzymology
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