Down‐regulated miR‐331–5p and miR‐27a are associated with chemotherapy resistance and relapse in leukaemia

Multidrug resistance (MDR) and disease relapse are challenging clinical problems in the treatment of leukaemia. Relapsed disease is frequently refractory to chemotherapy and exhibits multiple drug resistance. Therefore, it is important to identify the mechanism by which cancer cells develop resistan...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2011-10, Vol.15 (10), p.2164-2175
Hauptverfasser:	Feng, Dan‐Dan, Zhang, Hua, Zhang, Peng, Zheng, Yu‐Sheng, Zhang, Xing‐Ju, Han, Bo‐Wei, Luo, Xue‐Qun, Xu, Ling, Zhou, Hui, Qu, Liang‐Hu, Chen, Yue‐Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - therapeutic use ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Bone marrow Cancer therapies Cell Line, Tumor Cells Chemoresistance Chemotherapy Cluster analysis Disease resistance Down-Regulation Doxorubicin Doxorubicin - therapeutic use Drug resistance Drug Resistance, Neoplasm - genetics Female Flow cytometry Gene Expression Profiling Glycoproteins Humans Hypotheses K562 Cells leukaemia Leukemia Leukemia - drug therapy Male Medical prognosis MicroRNAs MicroRNAs - genetics miRNA miR‐27a miR‐331–5p Monoclonal antibodies Multidrug resistance P-Glycoprotein Patients Protein Biosynthesis Proteins Recurrence relapse Transfection
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