GATM polymorphism associated with the risk for statin-induced myopathy not replicated in case-control analysis of 715 dyslipidemic individuals
Statin-induced myopathy (SIM) is the most common reason for discontinuation of statin therapy. A polymorphism affecting the gene encoding glycine amidinotransferase ( GATM rs9806699 G>A) was previously associated with reduced risk for SIM. Our objective was to replicate the GATM association in a...
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| Veröffentlicht in: | Cell metabolism 2015-04, Vol.21 (4), p.622-627 |
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| creator | Luzum, Jasmine A. Kitzmiller, Joseph P. Isackson, Paul J. Ma, Changxing Medina, Marisa W. Dauki, Anees M. Mikulik, Eduard B. Ochs-Balcom, Heather M. Vladutiu, Georgirene D. |
| description | Statin-induced myopathy (SIM) is the most common reason for discontinuation of statin therapy. A polymorphism affecting the gene encoding glycine amidinotransferase (
GATM
rs9806699 G>A) was previously associated with reduced risk for SIM. Our objective was to replicate the
GATM
association in a large, multicenter SIM case-control study. Mild and severe SIM cases and age- and gender-matched controls were enrolled. Participants were genotyped, and associations were tested (n=715) using chi-square and logistic regression with consideration for SIM severity and exclusion of subjects with potentially confounding co-medications. The minor allele (A) frequencies of
GATM
rs9806699 in the controls (n=106), mild SIM (n=324), and severe SIM (n=285) cases were 0.26, 0.28, and 0.29, respectively (p=0.447). The unadjusted odds ratio for the A allele for any SIM (mild or severe) was 1.14 (0.82–1.61; p=0.437), which remained non-significant in all models. Our results do not replicate the association between
GATM
rs9806699 and SIM. |
| doi_str_mv | 10.1016/j.cmet.2015.03.003 |
| format | Article |
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GATM
rs9806699 G>A) was previously associated with reduced risk for SIM. Our objective was to replicate the
GATM
association in a large, multicenter SIM case-control study. Mild and severe SIM cases and age- and gender-matched controls were enrolled. Participants were genotyped, and associations were tested (n=715) using chi-square and logistic regression with consideration for SIM severity and exclusion of subjects with potentially confounding co-medications. The minor allele (A) frequencies of
GATM
rs9806699 in the controls (n=106), mild SIM (n=324), and severe SIM (n=285) cases were 0.26, 0.28, and 0.29, respectively (p=0.447). The unadjusted odds ratio for the A allele for any SIM (mild or severe) was 1.14 (0.82–1.61; p=0.437), which remained non-significant in all models. Our results do not replicate the association between
GATM
rs9806699 and SIM.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2015.03.003</identifier><identifier>PMID: 25863251</identifier><language>eng</language><ispartof>Cell metabolism, 2015-04, Vol.21 (4), p.622-627</ispartof><rights>2015 Published by Elsevier Inc. 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Luzum, Jasmine A.</creatorcontrib><creatorcontrib>Kitzmiller, Joseph P.</creatorcontrib><creatorcontrib>Isackson, Paul J.</creatorcontrib><creatorcontrib>Ma, Changxing</creatorcontrib><creatorcontrib>Medina, Marisa W.</creatorcontrib><creatorcontrib>Dauki, Anees M.</creatorcontrib><creatorcontrib>Mikulik, Eduard B.</creatorcontrib><creatorcontrib>Ochs-Balcom, Heather M.</creatorcontrib><creatorcontrib>Vladutiu, Georgirene D.</creatorcontrib><title>GATM polymorphism associated with the risk for statin-induced myopathy not replicated in case-control analysis of 715 dyslipidemic individuals</title><title>Cell metabolism</title><description>Statin-induced myopathy (SIM) is the most common reason for discontinuation of statin therapy. A polymorphism affecting the gene encoding glycine amidinotransferase (
GATM
rs9806699 G>A) was previously associated with reduced risk for SIM. Our objective was to replicate the
GATM
association in a large, multicenter SIM case-control study. Mild and severe SIM cases and age- and gender-matched controls were enrolled. Participants were genotyped, and associations were tested (n=715) using chi-square and logistic regression with consideration for SIM severity and exclusion of subjects with potentially confounding co-medications. The minor allele (A) frequencies of
GATM
rs9806699 in the controls (n=106), mild SIM (n=324), and severe SIM (n=285) cases were 0.26, 0.28, and 0.29, respectively (p=0.447). The unadjusted odds ratio for the A allele for any SIM (mild or severe) was 1.14 (0.82–1.61; p=0.437), which remained non-significant in all models. Our results do not replicate the association between
GATM
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GATM
rs9806699 G>A) was previously associated with reduced risk for SIM. Our objective was to replicate the
GATM
association in a large, multicenter SIM case-control study. Mild and severe SIM cases and age- and gender-matched controls were enrolled. Participants were genotyped, and associations were tested (n=715) using chi-square and logistic regression with consideration for SIM severity and exclusion of subjects with potentially confounding co-medications. The minor allele (A) frequencies of
GATM
rs9806699 in the controls (n=106), mild SIM (n=324), and severe SIM (n=285) cases were 0.26, 0.28, and 0.29, respectively (p=0.447). The unadjusted odds ratio for the A allele for any SIM (mild or severe) was 1.14 (0.82–1.61; p=0.437), which remained non-significant in all models. Our results do not replicate the association between
GATM
rs9806699 and SIM.</abstract><pmid>25863251</pmid><doi>10.1016/j.cmet.2015.03.003</doi></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| title | GATM polymorphism associated with the risk for statin-induced myopathy not replicated in case-control analysis of 715 dyslipidemic individuals |
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