SIRT3 Mediates Multi-Tissue Coupling for Metabolic Fuel Switching

SIRT3 is a member of the Sirtuin family of NAD+-dependent deacylases and plays a critical role in metabolic regulation. Organism-wide SIRT3 loss manifests in metabolic alterations; however, the coordinating role of SIRT3 among metabolically distinct tissues is unknown. Using multi-tissue quantitativ...

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Veröffentlicht in:	Cell metabolism 2015-04, Vol.21 (4), p.637-646
Hauptverfasser:	Dittenhafer-Reed, Kristin E., Richards, Alicia L., Fan, Jing, Smallegan, Michael J., Fotuhi Siahpirani, Alireza, Kemmerer, Zachary A., Prolla, Tomas A., Roy, Sushmita, Coon, Joshua J., Denu, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Brain - metabolism Computational Biology Gene Expression Regulation - physiology Homeostasis - physiology Ketone Bodies - metabolism Kidney - metabolism Liver - metabolism Metabolic Networks and Pathways - genetics Metabolic Networks and Pathways - physiology Mice Mice, Knockout Mitochondria - physiology Proteomics Sirtuin 3 - metabolism
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