Low birth weight activates the renin–angiotensin system, but limits cardiac angiogenesis in early postnatal life

Low birth weight (LBW) is associated with increased risk of adult cardiovascular disease and this association may be partly a consequence of early programming of the renin–angiotensin system (RAS). We investigated the effects of LBW on expression of molecules in the RAS and cardiac tissue remodeling...

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Veröffentlicht in:	Physiological reports 2015-02, Vol.3 (2), p.e12270-n/a
Hauptverfasser:	Wang, Kimberley C. W., Brooks, Doug A., Summers‐Pearce, Brooke, Bobrovskaya, Larisa, Tosh, Darran N., Duffield, Jaime A., Botting, Kimberley J., Zhang, Song, Caroline McMillen, I., Morrison, Janna L.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Acetylation Angiogenesis Angiotensin Angiotensin I Angiotensin II Angiotensin-converting enzyme 2 Animals Autophagy Birth weight Bisulfite Capillaries Cardiomyocytes Cardiovascular diseases Chromatin Deoxyribonucleic acid DNA DNA methylation Fibrosis Gene expression Growth factors Heart histone acetylation Hypertension Immunoprecipitation Kinases Low birth weight Neonates Original Research Phagocytosis Phosphorylation Physiology Protein expression Proteins Renin renin–angiotensin system Sheep Studies Surgery Vascular endothelial growth factor Ventricle Western blotting
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