Plasminogen Activator Inhibitor-1 Suppresses Profibrotic Responses in Fibroblasts from Fibrotic Lungs

Background: The long term survival outcome of patients with IPF is bleak, with a paucity of effective treatments. Results: The changes in baseline PAI-1 expression regulate fibroblast activation and expansion in fibrotic lung diseases. Conclusion: Targeted restoration, rather than inhibition of PAI-...

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Veröffentlicht in:	The Journal of biological chemistry 2015-04, Vol.290 (15), p.9428-9441
Hauptverfasser:	Marudamuthu, Amarnath S., Shetty, Shwetha K., Bhandary, Yashodhar P., Karandashova, Sophia, Thompson, Michael, Sathish, Venkatachalem, Florova, Galina, Hogan, Taryn B., Pabelick, Christina M., Prakash, Y.S., Tsukasaki, Yoshikazu, Fu, Jian, Ikebe, Mitsuo, Idell, Steven, Shetty, Sreerama
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Actins - metabolism Animal Model Animals Apoptosis - genetics Bleomycin Blotting, Western Cell Biology Cell Proliferation - genetics Cells, Cultured Collagen Type I - genetics Collagen Type I - metabolism Epithelial Cells - metabolism Epithelial Cells - pathology Fibroblast Fibroblasts - metabolism Fibroblasts - pathology Fibrosis Gene Expression Idiopathic Pulmonary Fibrosis - genetics Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - pathology Lung Mice, Inbred C57BL Mice, Knockout Microscopy, Confocal Muscle, Smooth - metabolism PAI-1 Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Pulmonary Fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Receptors, Urokinase Plasminogen Activator - genetics Receptors, Urokinase Plasminogen Activator - metabolism Reverse Transcriptase Polymerase Chain Reaction Urokinase-Type Plasminogen Activator - genetics Urokinase-Type Plasminogen Activator - metabolism
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