Granzyme B-induced mitochondrial ROS are required for apoptosis

Caspases and the cytotoxic lymphocyte protease granzyme B (GB) induce reactive oxygen species (ROS) formation, loss of transmembrane potential and mitochondrial outer membrane permeabilization (MOMP). Whether ROS are required for GB-mediated apoptosis and how GB induces ROS is unclear. Here, we foun...

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Veröffentlicht in:	Cell death and differentiation 2014-10, Vol.22 (5), p.862-874
Hauptverfasser:	Jacquemin, G, Margiotta, D, Kasahara, A, Bassoy, E Y, Walch, M, Thiery, J, Lieberman, J, Martinvalet, D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1933 82/58 96/2 96/31 96/95 Animals Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cytochrome Dehydrogenases Electron Transport Complex I - genetics Electron Transport Complex I - metabolism Electron Transport Complex III - genetics Electron Transport Complex III - metabolism Granzymes - genetics Granzymes - metabolism Humans K562 Cells Kinases Life Sciences Mass spectrometry Metabolism Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Mitochondrial Membranes - metabolism Original Paper Physiology Proteins Rats Reactive Oxygen Species - metabolism Respiration Scientific imaging Stem Cells
Online-Zugang:	Volltext
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