IL-35 mitigates murine acute graft-versus-host disease with retention of graft-versus-leukemia effects

IL-35 is a newly discovered inhibitory cytokine secreted by regulatory T cells (Tregs) and may have therapeutic potential in several inflammatory disorders. Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation and caused by donor T cel...

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Veröffentlicht in:	Leukemia 2015-04, Vol.29 (4), p.939-946
Hauptverfasser:	Liu, Y, Wu, Y, Wang, Y, Cai, Y, Hu, B, Bao, G, Fang, H, Zhao, L, Ma, S, Cheng, Q, Song, Y, Zhu, Z, Chang, H, Yu, X, Sun, A, Zhang, Y, Vignali, D A A, Wu, D, Liu, H
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/21 13/31 13/51 14/5 14/63 631/250/127 631/250/1904 64/60 692/699/249/1529 Acute Disease Animals Cancer Research Care and treatment CD4 antigen Cell activation Cell Proliferation Collaboration Critical Care Medicine Cytokines Female Foxp3 protein Gene expression Gene Expression Regulation, Leukemic Genetic aspects Graft versus host disease Graft versus host reaction Graft vs Host Disease - genetics Graft vs Host Disease - immunology Graft vs Host Disease - pathology Graft vs Leukemia Effect - immunology Graft-versus-leukemia reaction Grafting Health aspects Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Hospitals Humans Immunology Immunoregulation Inflammatory diseases Intensive Interferon-gamma - genetics Interferon-gamma - immunology Interleukin 10 Interleukin 22 Interleukin 23 Interleukin 6 Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-23 - genetics Interleukin-23 - immunology Interleukin-6 - genetics Interleukin-6 - immunology Interleukins Interleukins - genetics Interleukins - immunology Internal Medicine Laboratories Leukemia Leukemia - genetics Leukemia - immunology Leukemia - pathology Lymphocyte Activation Lymphocytes Lymphocytes T Male Medicine Medicine & Public Health Mice Oncology Organs original-article Risk factors Serum levels Signal Transduction Stem cell transplantation Stem cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology Th1 Cells - immunology Th1 Cells - pathology Transplantation Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-α γ-Interferon
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