A reliable method for the detection of BRCA1 and BRCA2 mutations in fixed tumour tissue utilising multiplex PCR-based targeted next generation sequencing

Germline mutations in BRCA1 or BRCA2 lead to a high lifetime probability of developing ovarian or breast cancer. These genes can also be involved in the development of non-hereditary tumours as somatic BRCA1/2 pathogenic variants are found in some of these cancers. Since patients with somatic BRCA p...

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Veröffentlicht in:	BMC clinical pathology 2015-03, Vol.15 (1), p.5-5, Article 5
Hauptverfasser:	Ellison, Gillian, Huang, Shuwen, Carr, Hedley, Wallace, Andrew, Ahdesmaki, Miika, Bhaskar, Sanjeev, Mills, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Cancer Development and progression DNA sequencing Formaldehyde Gene mutations Genetic aspects Genetic research Methods Monosaccharides Nucleotide sequencing Sugars Technical Advance
Online-Zugang:	Volltext
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