Outer membrane proteins preferentially load MHC class II peptides: Implications for a Chlamydia trachomatis T cell vaccine

Abstract CD4 T cell immune responses such as interferon-γ and tumor necrosis factor-α secretion are necessary for Chlamydia immunity. We used an immunoproteomic approach in which Chlamydia trachomatis and Chlamydia muridarum -derived peptides presented by MHC class II molecules on the surface of inf...

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Veröffentlicht in:	Vaccine 2015-04, Vol.33 (18), p.2159-2166
Hauptverfasser:	Karunakaran, Karuna P, Yu, Hong, Jiang, Xiaozhou, Chan, Queenie, Moon, Kyung-Mee, Foster, Leonard J, Brunham, Robert C
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvants Adjuvants, Immunologic Allergy and Immunology Animals Antibodies, Bacterial - immunology Antigen Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - immunology Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Bone marrow CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology Chlamydia Chlamydia Infections - immunology Chlamydia muridarum - chemistry Chlamydia muridarum - immunology Chlamydia trachomatis Chlamydia trachomatis - chemistry Chlamydia trachomatis - immunology Dehydrogenases dendritic cells Dendritic Cells - immunology Epitope epitopes Epitopes - immunology Female Histocompatibility Antigens Class II - immunology Humans immune response Immunoproteomics Infections interferon-gamma Lymphocytes Mass spectrometry Membranes MHC Mice Mice, Inbred C3H Mice, Inbred C57BL Molecular weight Outer membrane proteins Peptide Peptides Peptides - immunology Proteins Proteomics recombinant proteins Scientific imaging secretion serotypes Sexually transmitted diseases splenocytes STD subunit vaccines T cell Tandem Mass Spectrometry tumor necrosis factor-alpha Vaccine Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Women
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