PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation

Abstract Background Deregulated Ras/Raf/mitogen-activated protein kinase and PI3 K/AKT/mTOR signaling pathways are significant in hepatocellular carcinoma proliferation (HCC). In this study we evaluated differences in the antiproliferative effect of dual PI3 K/Akt/mTOR and Ras/Raf/mitogen-activated...

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Veröffentlicht in:	The Journal of surgical research 2013-11, Vol.185 (1), p.225-230
Hauptverfasser:	Gedaly, Roberto, MD, Galuppo, Roberto, MD, Musgrave, Yolanda, MD, Angulo, Paul, MD, Hundley, Jonathan, MD, Shah, Malay, MD, Daily, Michael F., MD, Chen, Changguo, PhD, Cohen, Donald A., PhD, Spear, Brett T., PhD, Evers, B. Mark, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation - drug effects Drug Therapy, Combination Hepatocellular carcinoma Humans Liver cancer stem cells Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology MAP Kinase Signaling System - drug effects Morpholines - pharmacology Neoplastic Stem Cells - cytology Neoplastic Stem Cells - drug effects Niacinamide - analogs & derivatives Niacinamide - pharmacology Phenylurea Compounds - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism PKI-587 Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins p21(ras) - metabolism raf Kinases - metabolism Signal Transduction - drug effects Sorafenib Surgery TOR Serine-Threonine Kinases - metabolism Triazines - pharmacology
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