Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells

BACKGROUND: The interconnected Ras/ERK and PI3K/AKT pathways play a central role in colorectal tumorigenesis, and they are targets for elucidating mechanisms involved in attempts to induce colon cancer cell death. Both ginger (Zingiber officinale) and honey have been shown to exhibit anti-tumor and...

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Veröffentlicht in:	Nutrition journal 2015-04, Vol.14 (1), p.31-15, Article 31
Hauptverfasser:	Tahir, Analhuda Abdullah, Sani, Nur Fathiah Abdul, Murad, Noor Azian, Makpol, Suzana, Ngah, Wan Zurinah Wan, Yusof, Yasmin Anum Mohd
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-inflammatory activity Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects Apoptosis - genetics bcl-X Protein - genetics Cancer carcinogenesis Care and treatment Caspase 9 - genetics caspases Cell death chemoprevention Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - pathology colorectal neoplasms death Down-Regulation - drug effects Drug Therapy, Combination - methods Gene Expression - drug effects gene expression regulation genes Genetic aspects ginger growth retardation Health aspects Honey HT29 Cells Humans Inflammation - drug therapy Inflammation - genetics inhibitory concentration 50 MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics mitogen-activated protein kinase neoplasm cells NF-kappaB-Inducing Kinase Oncogene Protein v-akt - genetics Oncology, Experimental Phytotherapy - methods Plant Extracts - chemistry Plant Extracts - pharmacology Plant Preparations - chemistry Plant Preparations - pharmacology Protein Serine-Threonine Kinases - genetics Protein Tyrosine Phosphatases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics synergism Treatment Outcome Up-Regulation - drug effects Zingiber officinale Zingiber officinale - chemistry
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