Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits

The lateral hypothalamus (LH) is a key regulator of multiple vital behaviors. The firing of brain-wide-projecting LH neurons releases neuropeptides promoting wakefulness (orexin/hypocretin; OH), or sleep (melanin-concentrating hormone; MCH). OH neurons, which coexpress glutamate and dynorphin, have...

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Veröffentlicht in:	The Journal of neuroscience 2015-04, Vol.35 (14), p.5435-5441
Hauptverfasser:	Apergis-Schoute, John, Iordanidou, Panagiota, Faure, Cedric, Jego, Sonia, Schöne, Cornelia, Aitta-Aho, Teemu, Adamantidis, Antoine, Burdakov, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brief Communications Calcium - metabolism Channelrhodopsins Excitatory Amino Acid Antagonists - pharmacology gamma-Aminobutyric Acid - metabolism Hypothalamic Area, Lateral - cytology Hypothalamic Area, Lateral - metabolism Hypothalamic Hormones - genetics Hypothalamic Hormones - metabolism In Vitro Techniques Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Luminescent Proteins - genetics Luminescent Proteins - metabolism Lysine - analogs & derivatives Lysine - metabolism Melanins - genetics Melanins - metabolism Membrane Potentials - drug effects Membrane Potentials - physiology Mice Nerve Net - physiology Neural Inhibition - drug effects Neural Inhibition - physiology Neurons - physiology Neuropeptides - genetics Neuropeptides - metabolism Neuropeptides - pharmacology Optogenetics Orexins Patch-Clamp Techniques Pituitary Hormones - genetics Pituitary Hormones - metabolism Red Fluorescent Protein Signal Transduction - physiology Transduction, Genetic
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