Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3

Many causal mutations of intellectual disability have been found in genes involved in epigenetic regulations. Replication‐independent deposition of the histone H3.3 variant by the HIRA complex is a prominent nucleosome replacement mechanism affecting gene transcription, especially in postmitotic neu...

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Veröffentlicht in:	EMBO reports 2015-04, Vol.16 (4), p.528-538
Hauptverfasser:	Chen, Wei-Yu, Shih, Hsueh-Tzu, Liu, Kuei-Yan, Shih, Zong-Siou, Chen, Li-Kai, Tsai, Tsung-Han, Chen, Mei-Ju, Liu, Hsuan, Tan, Bertrand Chin-Ming, Chen, Chien-Yu, Lee, Hsiu-Hsiang, Loppin, Benjamin, Aït-Ahmed, Ounissa, Wu, June-Tai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BRWD3 Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromatin Chromatin - chemistry Chromatin - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - antagonists & inhibitors Drosophila Proteins - genetics Drosophila Proteins - metabolism EMBO09 EMBO11 EMBO27 Gene expression Gene Expression Regulation, Developmental HIRA Histone Chaperones - genetics Histone Chaperones - metabolism histone H3.3 Histones - antagonists & inhibitors Histones - genetics Histones - metabolism Humans Inactivation intellectual disability Intellectual Disability - genetics Intellectual Disability - metabolism Intellectual Disability - pathology Kinases Life Sciences Morphogenesis - genetics Mutation Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Scientific Report Scientific Reports Sequence Homology, Amino Acid Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism YEM
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