Adeno-associated virus inverted terminal repeats stimulate gene editing

Advancements in genome editing have relied on technologies to specifically damage DNA which, in turn, stimulates DNA repair including homologous recombination (HR). As off-target concerns complicate the therapeutic translation of site-specific DNA endonucleases, an alternative strategy to stimulate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gene therapy 2015-02, Vol.22 (2), p.190-195
1. Verfasser:	Hirsch, M L
Format:	Artikel
Sprache:	eng
Schlagworte:	13/44 14/63 38/22 38/23 42/41 45/29 631/208/68 Adeno-associated virus Adenoviruses Base Sequence Biomedical and Life Sciences Biomedicine Cell Biology Deoxyribonucleic acid Dependovirus - genetics Dependoviruses DNA DNA Breaks, Double-Stranded DNA damage DNA Repair DNA structure Double-strand break repair Gene Expression Gene Therapy Genes Genes, Reporter Genes, Viral Genetic aspects Genetic Engineering Genetic research Genome editing Genomes Green Fluorescent Proteins - biosynthesis Green Fluorescent Proteins - genetics Health aspects HEK293 Cells Homologous recombination Human Genetics Humans Insertion Inverted Repeat Sequences Molecular Sequence Data MRE11 protein Nanotechnology Nucleotide sequence Oligonucleotides Polarity short-communication Terminal Repeat Sequences
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!