Suppressed autophagy flux in skeletal muscle of an amyotrophic lateral sclerosis mouse model during disease progression

Accumulation of abnormal protein inclusions is implicated in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Autophagy, an intracellular process targeting misfolded proteins and damaged organelles for lysosomal degradation, plays crucial roles in survival and diseased conditions. E...

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Veröffentlicht in:	Physiological reports 2015-01, Vol.3 (1), p.e12271-n/a
Hauptverfasser:	Xiao, Yajuan, Ma, Changling, Yi, Jianxun, Wu, Shaoping, Luo, Guo, Xu, Xiulong, Lin, Pei‐Hui, Sun, Jun, Zhou, Jingsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Apoptosis Autophagy cell physiology Colchicine Degeneration Lysosomes Musculoskeletal system Organelles Original Research Phagocytosis Physiology Protein folding Skeletal muscle
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