Differential roles of STAT3 in the initiation and growth of lung cancer

Signal transducer and activator of transcription 3 (STAT3) is linked to multiple cancers, including pulmonary adenocarcinoma. However, the role of STAT3 in lung cancer pathogenesis has not been determined. Using lung epithelial-specific inducible knockout strategies, we demonstrate that STAT3 has co...

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Veröffentlicht in:	Oncogene 2015-07, Vol.34 (29), p.3804-3814
Hauptverfasser:	Zhou, J, Qu, Z, Yan, S, Sun, F, Whitsett, J A, Shapiro, S D, Xiao, G
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/86 692/4028/67/1612 692/420/755 Adenocarcinoma Animals Apoptosis Carcinogens Cell Biology Cell growth Cell proliferation Cell Proliferation - genetics Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cells, Cultured Clonal deletion Development and progression Ethyl carbamate Gene deletion Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Health risk assessment Homeostasis Human Genetics Immunoblotting Immunohistochemistry Internal Medicine K-Ras protein Lung - metabolism Lung - pathology Lung cancer Lung Neoplasms - chemically induced Lung Neoplasms - genetics Lung Neoplasms - metabolism Medicine Medicine & Public Health Mice, Knockout Mice, Transgenic Mutation Oncology original-article Pneumonia - chemically induced Pneumonia - genetics Pneumonia - metabolism Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal transduction Smoke Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Transcription Tumor Burden - genetics Tumorigenesis Urethane Urethanes
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