Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

Metastatic progression, including extravasation and micrometastatic outgrowth, is the main cause of cancer patient death. Recent studies suggest that cancer cells reprogram their metabolism to support increased proliferation through increased glycolysis and biosynthetic activities, including lipogen...

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Veröffentlicht in:	Oncogene 2015-07, Vol.34 (30), p.3908-3916
Hauptverfasser:	Jiang, L, Xiao, L, Sugiura, H, Huang, X, Ali, A, Kuro-o, M, Deberardinis, R J, Boothman, D A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/84/2176 631/80/86 692/4028/67/2327 692/4028/67/322 Animals Apoptosis Carbohydrate Metabolism Cell Biology Cell Line, Tumor Cell Movement Cell proliferation Development and progression Enzyme Repression Epithelial cells Epithelial-Mesenchymal Transition Extravasation Fatty Acid Synthase, Type I - genetics Fatty Acid Synthase, Type I - metabolism Fatty acids Fatty-acid synthase Female Gene Expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glycolysis Health aspects Human Genetics Humans Internal Medicine Lipid Metabolism Lipogenesis Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - secondary Medicine Medicine & Public Health Mesenchyme Metabolism Metastases Metastasis Mice, Inbred NOD Mice, SCID Neoplasm Transplantation Oncology original-article Snail Family Transcription Factors Transcription Factors - physiology Transforming Growth Factor beta1 - physiology Transforming growth factor-b1 Transforming growth factors
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