Gene expression profiling of lobular carcinoma in situ reveals candidate precursor genes for invasion

Lobular carcinoma in situ (LCIS) is both a risk indicator and non-obligate precursor of invasive lobular carcinoma (ILC). We sought to characterize the transcriptomic features of LCIS and ILC, with a focus on the identification of intrinsic molecular subtypes of LCIS and the changes involved in the...

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Veröffentlicht in:	Molecular oncology 2015-04, Vol.9 (4), p.772-782
Hauptverfasser:	Andrade, Victor P., Morrogh, Mary, Qin, Li-Xuan, Olvera, Narciso, Giri, Dilip, Muhsen, Shirin, Sakr, Rita A., Schizas, Michail, Ng, Charlotte K.Y., Arroyo, Crispinita D., Brogi, Edi, Viale, Agnes, Morrow, Monica, Reis-Filho, Jorge S., King, Tari A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Apoptosis Breast Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinogenesis Carcinoma in Situ - genetics Carcinoma in Situ - pathology Carcinoma, Lobular - genetics Carcinoma, Lobular - pathology Chromosomes, Human - genetics Cluster Analysis Copy number Cytoskeleton Disease Progression DNA Copy Number Variations - genetics DNA microarrays Down-Regulation - genetics Epithelium Epithelium - pathology Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes, Neoplasm Genetic Association Studies Genetic Heterogeneity Genomics Humans Invasiveness Lasers Lobular carcinoma in situ Mastectomy Medical research Neoplasm Invasiveness - genetics p53 Protein Precursor Risk factor Signal transduction Software Wnt protein
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