Microglia inflammatory responses are controlled by an intrinsic circadian clock
Highlights • There are temporal differences in sickness behavior in rats. • Changes in sickness behavior are reflected in hippocampal cytokine and microglial responses. • Microglia show dramatic differences in immune activation throughout the day, with peak activation during the light phase. • Micro...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2015-03, Vol.45, p.171-179 |
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| container_title | Brain, behavior, and immunity |
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| creator | Fonken, Laura K Frank, Matthew G Kitt, Meagan M Barrientos, Ruth M Watkins, Linda R Maier, Steven F |
| description | Highlights • There are temporal differences in sickness behavior in rats. • Changes in sickness behavior are reflected in hippocampal cytokine and microglial responses. • Microglia show dramatic differences in immune activation throughout the day, with peak activation during the light phase. • Microglia rhythms are entrained by, but oscillate independent of, glucocorticoids. • These results suggest time-of-day should be considered when planning procedures that induce neuroinflammation. |
| doi_str_mv | 10.1016/j.bbi.2014.11.009 |
| format | Article |
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All rights reserved.</rights><rights>2014 Elsevier Inc. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-c80fc553c962f188b8a9b0077534c9ce0c85d712398a3d3cda9f6d37371f3e483</citedby><cites>FETCH-LOGICAL-c539t-c80fc553c962f188b8a9b0077534c9ce0c85d712398a3d3cda9f6d37371f3e483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbi.2014.11.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25433170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fonken, Laura K</creatorcontrib><creatorcontrib>Frank, Matthew G</creatorcontrib><creatorcontrib>Kitt, Meagan M</creatorcontrib><creatorcontrib>Barrientos, Ruth M</creatorcontrib><creatorcontrib>Watkins, Linda R</creatorcontrib><creatorcontrib>Maier, Steven F</creatorcontrib><title>Microglia inflammatory responses are controlled by an intrinsic circadian clock</title><title>Brain, behavior, and immunity</title><addtitle>Brain Behav Immun</addtitle><description>Highlights • There are temporal differences in sickness behavior in rats. • Changes in sickness behavior are reflected in hippocampal cytokine and microglial responses. • Microglia show dramatic differences in immune activation throughout the day, with peak activation during the light phase. • Microglia rhythms are entrained by, but oscillate independent of, glucocorticoids. • These results suggest time-of-day should be considered when planning procedures that induce neuroinflammation.</description><subject>Adrenalectomy</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Circadian</subject><subject>Circadian Clocks - drug effects</subject><subject>Circadian Clocks - immunology</subject><subject>Circadian Rhythm - drug effects</subject><subject>Clock gene</subject><subject>Corticosterone - pharmacology</subject><subject>Cytokines</subject><subject>Cytokines - drug effects</subject><subject>Cytokines - immunology</subject><subject>Glucocorticoids</subject><subject>Glucocorticoids - pharmacology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - immunology</subject><subject>Illness Behavior - drug effects</subject><subject>Illness Behavior - physiology</subject><subject>Inflammation</subject><subject>Interleukin-10 - genetics</subject><subject>Interleukin-10 - immunology</subject><subject>Interleukin-1beta - drug effects</subject><subject>Interleukin-1beta - genetics</subject><subject>Interleukin-1beta - immunology</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukin-6 - immunology</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Male</subject><subject>Microglia</subject><subject>Microglia - drug effects</subject><subject>Microglia - immunology</subject><subject>Psychiatry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - drug effects</subject><subject>RNA, Messenger - metabolism</subject><subject>Tumor Necrosis Factor-alpha - drug effects</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><issn>0889-1591</issn><issn>1090-2139</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkFv1DAQhSMEotvCD-CCcuSS4ImT2BZSJVQVilTUA3C2nMmkeOvYi52ttP8eR1sq4IA4WbLfexq_b4riFbAaGPRvt_Uw2Lph0NYANWPqSbEBpljVAFdPiw2TUlXQKTgpTlPaMsY6DvJ5cdJ0Lecg2Ka4-WwxhltnTWn95Mw8myXEQxkp7YJPlEoTqcTglxico7EcDqXxWbtE65PFEm1EM9p8hy7g3Yvi2WRcopcP51nx7cPl14ur6vrm46eL99cVdlwtFUo2YddxVH0zgZSDNGpgTIiOt6iQGMpuFNBwJQ0fOY5GTf3IBRcwcWolPyvOj7m7_TDTiJQHMk7vop1NPOhgrP7zxdvv-jbc65bLvudrwJuHgBh-7CkterYJyTnjKeyTBtGIXkjxP9K-k4K1bdNnKRyludSUIk2PEwHTKzO91ZmZXplpAJ2ZZc_r37_y6PgFKQveHQWUC723FHVCSx5ptJFw0WOw_4w__8uNznqLxt3RgdI27KPPpDTo1Gimv6xLs-4MtHldmlz1Txa1vPg</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Fonken, Laura K</creator><creator>Frank, Matthew G</creator><creator>Kitt, Meagan M</creator><creator>Barrientos, Ruth M</creator><creator>Watkins, Linda R</creator><creator>Maier, Steven F</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20150301</creationdate><title>Microglia inflammatory responses are controlled by an intrinsic circadian clock</title><author>Fonken, Laura K ; Frank, Matthew G ; Kitt, Meagan M ; Barrientos, Ruth M ; Watkins, Linda R ; Maier, Steven F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-c80fc553c962f188b8a9b0077534c9ce0c85d712398a3d3cda9f6d37371f3e483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adrenalectomy</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Circadian</topic><topic>Circadian Clocks - drug effects</topic><topic>Circadian Clocks - immunology</topic><topic>Circadian Rhythm - drug effects</topic><topic>Clock gene</topic><topic>Corticosterone - pharmacology</topic><topic>Cytokines</topic><topic>Cytokines - drug effects</topic><topic>Cytokines - immunology</topic><topic>Glucocorticoids</topic><topic>Glucocorticoids - pharmacology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - immunology</topic><topic>Illness Behavior - drug effects</topic><topic>Illness Behavior - physiology</topic><topic>Inflammation</topic><topic>Interleukin-10 - genetics</topic><topic>Interleukin-10 - immunology</topic><topic>Interleukin-1beta - drug effects</topic><topic>Interleukin-1beta - genetics</topic><topic>Interleukin-1beta - immunology</topic><topic>Interleukin-6 - genetics</topic><topic>Interleukin-6 - immunology</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Male</topic><topic>Microglia</topic><topic>Microglia - drug effects</topic><topic>Microglia - immunology</topic><topic>Psychiatry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - drug effects</topic><topic>RNA, Messenger - metabolism</topic><topic>Tumor Necrosis Factor-alpha - drug effects</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fonken, Laura K</creatorcontrib><creatorcontrib>Frank, Matthew G</creatorcontrib><creatorcontrib>Kitt, Meagan M</creatorcontrib><creatorcontrib>Barrientos, Ruth M</creatorcontrib><creatorcontrib>Watkins, Linda R</creatorcontrib><creatorcontrib>Maier, Steven F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain, behavior, and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fonken, Laura K</au><au>Frank, Matthew G</au><au>Kitt, Meagan M</au><au>Barrientos, Ruth M</au><au>Watkins, Linda R</au><au>Maier, Steven F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microglia inflammatory responses are controlled by an intrinsic circadian clock</atitle><jtitle>Brain, behavior, and immunity</jtitle><addtitle>Brain Behav Immun</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>45</volume><spage>171</spage><epage>179</epage><pages>171-179</pages><issn>0889-1591</issn><eissn>1090-2139</eissn><abstract>Highlights • There are temporal differences in sickness behavior in rats. • Changes in sickness behavior are reflected in hippocampal cytokine and microglial responses. • Microglia show dramatic differences in immune activation throughout the day, with peak activation during the light phase. • Microglia rhythms are entrained by, but oscillate independent of, glucocorticoids. • These results suggest time-of-day should be considered when planning procedures that induce neuroinflammation.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>25433170</pmid><doi>10.1016/j.bbi.2014.11.009</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenalectomy Allergy and Immunology Animals Circadian Circadian Clocks - drug effects Circadian Clocks - immunology Circadian Rhythm - drug effects Clock gene Corticosterone - pharmacology Cytokines Cytokines - drug effects Cytokines - immunology Glucocorticoids Glucocorticoids - pharmacology Hippocampus - drug effects Hippocampus - immunology Illness Behavior - drug effects Illness Behavior - physiology Inflammation Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-1beta - drug effects Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukin-6 - genetics Interleukin-6 - immunology Lipopolysaccharides - pharmacology Male Microglia Microglia - drug effects Microglia - immunology Psychiatry Rats Rats, Sprague-Dawley RNA, Messenger - drug effects RNA, Messenger - metabolism Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology |
| title | Microglia inflammatory responses are controlled by an intrinsic circadian clock |
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