Adoptive T‐cell immunotherapy for ganciclovir‐resistant CMV disease after lung transplantation
Infections with cytomegalovirus (CMV) can induce severe complications after solid organ transplantation (SOT). The prognosis for ganciclovir‐resistant CMV infection and disease is particularly poor. Whereas adoptive transfer of CMV‐specific T cells has emerged as a powerful tool in hematopoietic ste...
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| Veröffentlicht in: | Clinical & translational immunology 2015-03, Vol.4 (3), p.e35-n/a |
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| creator | Holmes‐Liew, Chien‐Li Holmes, Mark Beagley, Leone Hopkins, Peter Chambers, Daniel Smith, Corey Khanna, Rajiv |
| description | Infections with cytomegalovirus (CMV) can induce severe complications after solid organ transplantation (SOT). The prognosis for ganciclovir‐resistant CMV infection and disease is particularly poor. Whereas adoptive transfer of CMV‐specific T cells has emerged as a powerful tool in hematopoietic stem cell transplant patients, its translation into the SOT setting remains a significant challenge as underlying immunosuppression inhibits the virus‐specific T‐cell response in vivo. Here, we demonstrate successful expansion and adoptive transfer of autologous CMV‐specific T cells from a seronegative recipient of a seropositive lung allograft with ganciclovir‐resistant CMV disease, resulting in the long‐term reconstitution of protective anti‐viral immunity, CMV infection, disease‐free survival and no allograft rejection. |
| doi_str_mv | 10.1038/cti.2015.5 |
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The prognosis for ganciclovir‐resistant CMV infection and disease is particularly poor. Whereas adoptive transfer of CMV‐specific T cells has emerged as a powerful tool in hematopoietic stem cell transplant patients, its translation into the SOT setting remains a significant challenge as underlying immunosuppression inhibits the virus‐specific T‐cell response in vivo. Here, we demonstrate successful expansion and adoptive transfer of autologous CMV‐specific T cells from a seronegative recipient of a seropositive lung allograft with ganciclovir‐resistant CMV disease, resulting in the long‐term reconstitution of protective anti‐viral immunity, CMV infection, disease‐free survival and no allograft rejection.</description><identifier>ISSN: 2050-0068</identifier><identifier>EISSN: 2050-0068</identifier><identifier>DOI: 10.1038/cti.2015.5</identifier><identifier>PMID: 25859390</identifier><language>eng</language><publisher>Australia: Nature Publishing Group</publisher><subject>Adoptive transfer ; Antiviral drugs ; Autografts ; Case Report ; Cytokines ; Cytomegalovirus ; Deoxyribonucleic acid ; DNA ; Ganciclovir ; Graft rejection ; Hematopoietic stem cells ; Immunosuppression ; Immunotherapy ; Lung diseases ; Lung transplantation ; Lymphocytes ; Lymphocytes T ; Medical prognosis ; Mortality ; Mutation ; Patients ; Peptides ; Software ; Stem cell transplantation ; Transplants & implants ; Xenografts</subject><ispartof>Clinical & translational immunology, 2015-03, Vol.4 (3), p.e35-n/a</ispartof><rights>2015 The Authors</rights><rights>2015. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2015 Australasian Society for Immunology Inc. 2015 Australasian Society for Immunology Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3775-a586938ef17a64276578f23c96b400334a8695809ad556e2d5e882a7b3862b253</citedby><cites>FETCH-LOGICAL-c3775-a586938ef17a64276578f23c96b400334a8695809ad556e2d5e882a7b3862b253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386617/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386617/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25859390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmes‐Liew, Chien‐Li</creatorcontrib><creatorcontrib>Holmes, Mark</creatorcontrib><creatorcontrib>Beagley, Leone</creatorcontrib><creatorcontrib>Hopkins, Peter</creatorcontrib><creatorcontrib>Chambers, Daniel</creatorcontrib><creatorcontrib>Smith, Corey</creatorcontrib><creatorcontrib>Khanna, Rajiv</creatorcontrib><title>Adoptive T‐cell immunotherapy for ganciclovir‐resistant CMV disease after lung transplantation</title><title>Clinical & translational immunology</title><addtitle>Clin Transl Immunology</addtitle><description>Infections with cytomegalovirus (CMV) can induce severe complications after solid organ transplantation (SOT). The prognosis for ganciclovir‐resistant CMV infection and disease is particularly poor. Whereas adoptive transfer of CMV‐specific T cells has emerged as a powerful tool in hematopoietic stem cell transplant patients, its translation into the SOT setting remains a significant challenge as underlying immunosuppression inhibits the virus‐specific T‐cell response in vivo. Here, we demonstrate successful expansion and adoptive transfer of autologous CMV‐specific T cells from a seronegative recipient of a seropositive lung allograft with ganciclovir‐resistant CMV disease, resulting in the long‐term reconstitution of protective anti‐viral immunity, CMV infection, disease‐free survival and no allograft rejection.</description><subject>Adoptive transfer</subject><subject>Antiviral drugs</subject><subject>Autografts</subject><subject>Case Report</subject><subject>Cytokines</subject><subject>Cytomegalovirus</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Ganciclovir</subject><subject>Graft rejection</subject><subject>Hematopoietic stem cells</subject><subject>Immunosuppression</subject><subject>Immunotherapy</subject><subject>Lung diseases</subject><subject>Lung transplantation</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical prognosis</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Patients</subject><subject>Peptides</subject><subject>Software</subject><subject>Stem cell transplantation</subject><subject>Transplants & implants</subject><subject>Xenografts</subject><issn>2050-0068</issn><issn>2050-0068</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1qFTEYhoMottRuvAAJuBHhHL8kk5_ZCOXgT6HFzdFtyMxkTlNmkjHJHDk7L8Fr9ErMcNpSXbjKB9_Dkzd5EXpJYE2AqXdtdmsKhK_5E3RKgcMKQKinj-YTdJ7SLQAQVgEn4jk6oVzxmtVwipqLLkzZ7S3e_v75q7XDgN04zj7kGxvNdMB9iHhnfOvaIexdLFC0yaVsfMab62-4c8maZLHps414mP0O52h8moZCmOyCf4Ge9WZI9vzuPENfP37Ybj6vrr58utxcXK1aJiVfGa5EzZTtiTSiolJwqXrK2lo0FQBjlSl7rqA2HefC0o5bpaiRDVOCNpSzM_T-6J3mZrRda30JMugputHEgw7G6b833t3oXdjrqhgEkUXw5k4Qw_fZpqxHl5YvMd6GOWkilaylZHK56_U_6G2Yoy_P05TWQAmj9SJ8e6TaGFKKtn8IQ0Av7enSnl7a04vy1eP4D-h9VwWAI_DDDfbwH5XebC-XibM_Xk-mmQ</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Holmes‐Liew, Chien‐Li</creator><creator>Holmes, Mark</creator><creator>Beagley, Leone</creator><creator>Hopkins, Peter</creator><creator>Chambers, Daniel</creator><creator>Smith, Corey</creator><creator>Khanna, Rajiv</creator><general>Nature Publishing Group</general><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201503</creationdate><title>Adoptive T‐cell immunotherapy for ganciclovir‐resistant CMV disease after lung transplantation</title><author>Holmes‐Liew, Chien‐Li ; Holmes, Mark ; Beagley, Leone ; Hopkins, Peter ; Chambers, Daniel ; Smith, Corey ; Khanna, Rajiv</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3775-a586938ef17a64276578f23c96b400334a8695809ad556e2d5e882a7b3862b253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adoptive transfer</topic><topic>Antiviral drugs</topic><topic>Autografts</topic><topic>Case Report</topic><topic>Cytokines</topic><topic>Cytomegalovirus</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Ganciclovir</topic><topic>Graft rejection</topic><topic>Hematopoietic stem cells</topic><topic>Immunosuppression</topic><topic>Immunotherapy</topic><topic>Lung diseases</topic><topic>Lung transplantation</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medical prognosis</topic><topic>Mortality</topic><topic>Mutation</topic><topic>Patients</topic><topic>Peptides</topic><topic>Software</topic><topic>Stem cell transplantation</topic><topic>Transplants & implants</topic><topic>Xenografts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holmes‐Liew, Chien‐Li</creatorcontrib><creatorcontrib>Holmes, Mark</creatorcontrib><creatorcontrib>Beagley, Leone</creatorcontrib><creatorcontrib>Hopkins, Peter</creatorcontrib><creatorcontrib>Chambers, Daniel</creatorcontrib><creatorcontrib>Smith, Corey</creatorcontrib><creatorcontrib>Khanna, Rajiv</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical & translational immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holmes‐Liew, Chien‐Li</au><au>Holmes, Mark</au><au>Beagley, Leone</au><au>Hopkins, Peter</au><au>Chambers, Daniel</au><au>Smith, Corey</au><au>Khanna, Rajiv</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adoptive T‐cell immunotherapy for ganciclovir‐resistant CMV disease after lung transplantation</atitle><jtitle>Clinical & translational immunology</jtitle><addtitle>Clin Transl Immunology</addtitle><date>2015-03</date><risdate>2015</risdate><volume>4</volume><issue>3</issue><spage>e35</spage><epage>n/a</epage><pages>e35-n/a</pages><issn>2050-0068</issn><eissn>2050-0068</eissn><abstract>Infections with cytomegalovirus (CMV) can induce severe complications after solid organ transplantation (SOT). 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| source | Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adoptive transfer Antiviral drugs Autografts Case Report Cytokines Cytomegalovirus Deoxyribonucleic acid DNA Ganciclovir Graft rejection Hematopoietic stem cells Immunosuppression Immunotherapy Lung diseases Lung transplantation Lymphocytes Lymphocytes T Medical prognosis Mortality Mutation Patients Peptides Software Stem cell transplantation Transplants & implants Xenografts |
| title | Adoptive T‐cell immunotherapy for ganciclovir‐resistant CMV disease after lung transplantation |
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