Prostate cancer: beware of disseminated intravascular coagulation
Disseminated intravascular coagulation (DIC) is a pathological systemic condition resulting from aberrant activation of the coagulation system. It is characterised by the release and activation of procoagulants into the blood, with an associated consumption coagulopathy. Its association with solid a...
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| Veröffentlicht in: | BMJ case reports 2015-03, Vol.2015, p.bcr2014206814 |
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| creator | Desai, Mihir John, Babbin Evans, Gillian Eddy, Ben |
| description | Disseminated intravascular coagulation (DIC) is a pathological systemic condition resulting from aberrant activation of the coagulation system. It is characterised by the release and activation of procoagulants into the blood, with an associated consumption coagulopathy. Its association with solid and haematological malignancies is well described in literature. This case describes an elderly man, known to have prostate cancer, who following transurethral resection of the prostate developed DIC with haematuria, spontaneous ecchymoses and mucosal bleeding. Subsequent investigations revealed a prostate-specific antigen (PSA) >1000 µg/L, and staging CT showed multiple sclerotic metastatic lesions affecting the thoracic and lumbar vertebra, as well as infiltration into his left femur. Coagulation normalised with blood products and vitamin K within 1 week, and the patient responded to antiandrogen therapy with a reduction in pain and PSA on discharge. |
| doi_str_mv | 10.1136/bcr-2014-206814 |
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It is characterised by the release and activation of procoagulants into the blood, with an associated consumption coagulopathy. Its association with solid and haematological malignancies is well described in literature. This case describes an elderly man, known to have prostate cancer, who following transurethral resection of the prostate developed DIC with haematuria, spontaneous ecchymoses and mucosal bleeding. Subsequent investigations revealed a prostate-specific antigen (PSA) >1000 µg/L, and staging CT showed multiple sclerotic metastatic lesions affecting the thoracic and lumbar vertebra, as well as infiltration into his left femur. 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It is characterised by the release and activation of procoagulants into the blood, with an associated consumption coagulopathy. Its association with solid and haematological malignancies is well described in literature. This case describes an elderly man, known to have prostate cancer, who following transurethral resection of the prostate developed DIC with haematuria, spontaneous ecchymoses and mucosal bleeding. Subsequent investigations revealed a prostate-specific antigen (PSA) >1000 µg/L, and staging CT showed multiple sclerotic metastatic lesions affecting the thoracic and lumbar vertebra, as well as infiltration into his left femur. Coagulation normalised with blood products and vitamin K within 1 week, and the patient responded to antiandrogen therapy with a reduction in pain and PSA on discharge.</description><subject>80 years</subject><subject>Aged, 80 and over</subject><subject>Androgen Antagonists - administration & dosage</subject><subject>Antifibrinolytic Agents - administration & dosage</subject><subject>Biomarkers, Tumor - blood</subject><subject>Blood platelets</subject><subject>Diagnosis, Differential</subject><subject>Disseminated Intravascular Coagulation - etiology</subject><subject>Disseminated Intravascular Coagulation - prevention & control</subject><subject>Hematuria - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Metastasis</subject><subject>Prostate cancer</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatic Neoplasms - complications</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Reminder of Important Clinical Lesson</subject><subject>Spinal Neoplasms - secondary</subject><subject>Thrombosis</subject><subject>Treatment Outcome</subject><subject>United Kingdom</subject><subject>Vitamin K - administration & dosage</subject><subject>White</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1LxDAQxYMouqx79iYFLyJUM5umST0IsvgFC3pQ8BbSZKpd2kaTVvG_N8uuol7MIRmYXx5v5hGyB_QYgOUnpfHplEIWr1xCtkFGILhIRUEfN3_UO2QSwoLGwyCTGdsmO1MuoZDAR-T8zrvQ6x4TozuD_jQp8V17TFyV2DoEbOsudm1Sd73XbzqYodE-MU4_xaKvXbdLtirdBJys3zF5uLy4n12n89urm9n5PC2ZiB4BtS4B0WohtDSGRntVhUVmLOfUMhsbQEHSApmhJRWWScsBuRC5hRLZmJytdF-GskVrcGmoUS--brX_UE7X6nenq5_Vk3tTGZM5Ax4FDtcC3r0OGHrV1sFg0-gO3RAU5LkouOA5RPTgD7pwg-_ieApkxuPOp8WSOllRJu4weKy-zQBVy4RUTEgtE1KrhOKP_Z8zfPNfeUTgaAWU7eJftU9fYJpv</recordid><startdate>20150327</startdate><enddate>20150327</enddate><creator>Desai, Mihir</creator><creator>John, Babbin</creator><creator>Evans, Gillian</creator><creator>Eddy, Ben</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150327</creationdate><title>Prostate cancer: beware of disseminated intravascular coagulation</title><author>Desai, Mihir ; 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It is characterised by the release and activation of procoagulants into the blood, with an associated consumption coagulopathy. Its association with solid and haematological malignancies is well described in literature. This case describes an elderly man, known to have prostate cancer, who following transurethral resection of the prostate developed DIC with haematuria, spontaneous ecchymoses and mucosal bleeding. Subsequent investigations revealed a prostate-specific antigen (PSA) >1000 µg/L, and staging CT showed multiple sclerotic metastatic lesions affecting the thoracic and lumbar vertebra, as well as infiltration into his left femur. Coagulation normalised with blood products and vitamin K within 1 week, and the patient responded to antiandrogen therapy with a reduction in pain and PSA on discharge.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>25819815</pmid><doi>10.1136/bcr-2014-206814</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 80 years Aged, 80 and over Androgen Antagonists - administration & dosage Antifibrinolytic Agents - administration & dosage Biomarkers, Tumor - blood Blood platelets Diagnosis, Differential Disseminated Intravascular Coagulation - etiology Disseminated Intravascular Coagulation - prevention & control Hematuria - etiology Humans Male Metastasis Prostate cancer Prostate-Specific Antigen - blood Prostatic Neoplasms - complications Prostatic Neoplasms - pathology Reminder of Important Clinical Lesson Spinal Neoplasms - secondary Thrombosis Treatment Outcome United Kingdom Vitamin K - administration & dosage White |
| title | Prostate cancer: beware of disseminated intravascular coagulation |
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