A case of hypersensitivity to soluble and isophane insulins but not to insulin glargine
Insulin is an important agent for the treatment of diabetes mellitus (DM). Allergic reactions to insulin therapy, although rare, have been evident since animal insulin became available for the treatment of DM in 1922. Hypersensitivity to insulin has considerably been reduced with the introduction of...
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| Veröffentlicht in: | Indian journal of pharmacology 2015-03, Vol.47 (2), p.227-229 |
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| container_title | Indian journal of pharmacology |
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| creator | Belhekar, Mahesh N Pai, Sarayu Tayade, Parimal Dalwadi, Pradip Munshi, Renuka Varthakavi, Prema |
| description | Insulin is an important agent for the treatment of diabetes mellitus (DM). Allergic reactions to insulin therapy, although rare, have been evident since animal insulin became available for the treatment of DM in 1922. Hypersensitivity to insulin has considerably been reduced with the introduction of human insulin produced by recombinant deoxyribonucleic acid technology. Here, we present a case of Type 2 DM who demonstrated immediate (Type 1) hypersensitivity reaction on the sites of subcutaneous injection of soluble and isophane insulin but insulin glargine was tolerated well and provided good glycemic control. |
| doi_str_mv | 10.4103/0253-7613.153438 |
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Allergic reactions to insulin therapy, although rare, have been evident since animal insulin became available for the treatment of DM in 1922. Hypersensitivity to insulin has considerably been reduced with the introduction of human insulin produced by recombinant deoxyribonucleic acid technology. Here, we present a case of Type 2 DM who demonstrated immediate (Type 1) hypersensitivity reaction on the sites of subcutaneous injection of soluble and isophane insulin but insulin glargine was tolerated well and provided good glycemic control.</description><identifier>ISSN: 0253-7613</identifier><identifier>EISSN: 1998-3751</identifier><identifier>DOI: 10.4103/0253-7613.153438</identifier><identifier>PMID: 25878390</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. 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Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Apr 2015</rights><rights>Copyright: © Indian Journal of Pharmacology 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-50c8a49f99249a25afb349c424d57a4cae93a44fc00ebe2573151dd825433ed93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386139/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386139/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25878390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belhekar, Mahesh N</creatorcontrib><creatorcontrib>Pai, Sarayu</creatorcontrib><creatorcontrib>Tayade, Parimal</creatorcontrib><creatorcontrib>Dalwadi, Pradip</creatorcontrib><creatorcontrib>Munshi, Renuka</creatorcontrib><creatorcontrib>Varthakavi, Prema</creatorcontrib><title>A case of hypersensitivity to soluble and isophane insulins but not to insulin glargine</title><title>Indian journal of pharmacology</title><addtitle>Indian J Pharmacol</addtitle><description>Insulin is an important agent for the treatment of diabetes mellitus (DM). Allergic reactions to insulin therapy, although rare, have been evident since animal insulin became available for the treatment of DM in 1922. Hypersensitivity to insulin has considerably been reduced with the introduction of human insulin produced by recombinant deoxyribonucleic acid technology. Here, we present a case of Type 2 DM who demonstrated immediate (Type 1) hypersensitivity reaction on the sites of subcutaneous injection of soluble and isophane insulin but insulin glargine was tolerated well and provided good glycemic control.</description><subject>Adult</subject><subject>Allergies</subject><subject>Blood Glucose - analysis</subject><subject>Case studies</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Dosage and administration</subject><subject>Drug hypersensitivity</subject><subject>Drug Watch</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - blood</subject><subject>Hypersensitivity, Immediate - chemically induced</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Immunoglobulin E - blood</subject><subject>Insulin</subject><subject>Insulin Glargine - administration & dosage</subject><subject>Insulin Glargine - adverse effects</subject><subject>Insulin Glargine - therapeutic use</subject><subject>Insulin, Isophane - administration & dosage</subject><subject>Insulin, Isophane - adverse effects</subject><subject>Insulin, Isophane - therapeutic use</subject><subject>Insulin, Regular, Pork - administration & dosage</subject><subject>Insulin, Regular, Pork - adverse effects</subject><subject>Insulin, Regular, Pork - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0253-7613</issn><issn>1998-3751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUk2LFDEUDKK44-rdkwS8eOkxn92dizAsugoLXhSPIZ1-3ZMlk4xJ98L8e9PM7OjKEEjIe1WVvKIQekvJWlDCPxImedXUlK-p5IK3z9CKKtVWvJH0OVqd21foVc73pNyFql-iKybbpuWKrNCvDbYmA44D3h72kDKE7Cb34KYDniLO0c-dB2xCj12O-60JgF3Isy8b7uYJhzgtwFMNj96k0QV4jV4Mxmd4czqv0c8vn3_cfK3uvt9-u9ncVVYyNVWS2NYINSjFhDJMmqHjQlnBRC8bI6wBxY0QgyUEOmCy4VTSvm_LIJxDr_g1-nTU3c_dDnoLYUrG631yO5MOOhqnn3aC2-oxPujiVjFmEfhwEkjx9wx50juXLXhfJo1z1rRuBCM1obxA3_8HvY9zCmW8BVXLmnBG_6JG40G7MMTyrl1E9UaQWtG2bhat6gJqhADlkzHA4Er5CX59AV9WDztnLxLIkWBTzDnBcPaEEr2ERy_p0Es69DE8hfLuXy_PhMe08D9pl73X</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Belhekar, Mahesh N</creator><creator>Pai, Sarayu</creator><creator>Tayade, Parimal</creator><creator>Dalwadi, Pradip</creator><creator>Munshi, Renuka</creator><creator>Varthakavi, Prema</creator><general>Medknow Publications and Media Pvt. 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Tayade, Parimal ; Dalwadi, Pradip ; Munshi, Renuka ; Varthakavi, Prema</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-50c8a49f99249a25afb349c424d57a4cae93a44fc00ebe2573151dd825433ed93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Allergies</topic><topic>Blood Glucose - analysis</topic><topic>Case studies</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Dosage and administration</topic><topic>Drug hypersensitivity</topic><topic>Drug Watch</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - blood</topic><topic>Hypersensitivity, Immediate - chemically induced</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Immunoglobulin E - blood</topic><topic>Insulin</topic><topic>Insulin Glargine - administration & dosage</topic><topic>Insulin Glargine - adverse effects</topic><topic>Insulin Glargine - therapeutic use</topic><topic>Insulin, Isophane - administration & dosage</topic><topic>Insulin, Isophane - adverse effects</topic><topic>Insulin, Isophane - therapeutic use</topic><topic>Insulin, Regular, Pork - administration & dosage</topic><topic>Insulin, Regular, Pork - adverse effects</topic><topic>Insulin, Regular, Pork - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belhekar, Mahesh N</creatorcontrib><creatorcontrib>Pai, Sarayu</creatorcontrib><creatorcontrib>Tayade, Parimal</creatorcontrib><creatorcontrib>Dalwadi, Pradip</creatorcontrib><creatorcontrib>Munshi, Renuka</creatorcontrib><creatorcontrib>Varthakavi, Prema</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belhekar, Mahesh N</au><au>Pai, Sarayu</au><au>Tayade, Parimal</au><au>Dalwadi, Pradip</au><au>Munshi, Renuka</au><au>Varthakavi, Prema</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of hypersensitivity to soluble and isophane insulins but not to insulin glargine</atitle><jtitle>Indian journal of pharmacology</jtitle><addtitle>Indian J Pharmacol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>47</volume><issue>2</issue><spage>227</spage><epage>229</epage><pages>227-229</pages><issn>0253-7613</issn><eissn>1998-3751</eissn><abstract>Insulin is an important agent for the treatment of diabetes mellitus (DM). Allergic reactions to insulin therapy, although rare, have been evident since animal insulin became available for the treatment of DM in 1922. Hypersensitivity to insulin has considerably been reduced with the introduction of human insulin produced by recombinant deoxyribonucleic acid technology. Here, we present a case of Type 2 DM who demonstrated immediate (Type 1) hypersensitivity reaction on the sites of subcutaneous injection of soluble and isophane insulin but insulin glargine was tolerated well and provided good glycemic control.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>25878390</pmid><doi>10.4103/0253-7613.153438</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Indian journal of pharmacology, 2015-03, Vol.47 (2), p.227-229 |
| issn | 0253-7613 1998-3751 |
| language | eng |
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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Allergies Blood Glucose - analysis Case studies Complications and side effects Diabetes Dosage and administration Drug hypersensitivity Drug Watch Female Humans Hypersensitivity, Immediate - blood Hypersensitivity, Immediate - chemically induced Hypersensitivity, Immediate - immunology Immunoglobulin E - blood Insulin Insulin Glargine - administration & dosage Insulin Glargine - adverse effects Insulin Glargine - therapeutic use Insulin, Isophane - administration & dosage Insulin, Isophane - adverse effects Insulin, Isophane - therapeutic use Insulin, Regular, Pork - administration & dosage Insulin, Regular, Pork - adverse effects Insulin, Regular, Pork - therapeutic use Treatment Outcome |
| title | A case of hypersensitivity to soluble and isophane insulins but not to insulin glargine |
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